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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2797-2804

2000

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Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Nature structural & molecular biology, 2002-10, Vol.9 (10), p.745-749

2002

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Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O6-Substituted Guanine Derivatives

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3381-3393

2002

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4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (2), p.217-222

2003

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Resistance-Modifying Agents. 8. Inhibition of O 6-Alkylguanine-DNA Alkyltransferase by O 6-Alkenyl-, O 6-Cycloalkenyl-, and O 6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O 6-(1-Cyclopentenylmethyl)guanine

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4071-4083

2000

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N 2 -Substituted O 6 -Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3710-3722

2004

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DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

European journal of cancer (1990), 2002-07, Vol.38 (11), p.1543-1552

2002

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Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3381-3393

2002

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Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients

Biochimica et biophysica acta, 2003-05, Vol.1638 (1), p.20-28

2003

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Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4071

2000

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N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3710-3722

2004

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Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6-Substituted Guanine Derivatives

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3381-3393

2002

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Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4071-4083

2000

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High HIV seroprevalence and increased HIV-associated mortality among hospitalized patients with deep bacterial infections in Dar es Salaam, Tanzania

AIDS (London), 1992-09, Vol.6 (9), p.971-976

1992

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Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFα

Biochimica et biophysica acta. Gene structure and expression, 2003-04, Vol.1626 (1), p.83-91

2003

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Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines)

Anti-cancer drug design, 1994-10, Vol.9 (5), p.401

1994

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Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha

Biochimica et biophysica acta, 2003-04, Vol.1626 (1-3), p.83

2003

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N2-Substituted O 6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3710-3722

2004

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On Boussinesq and Coriolis coefficients and their derivatives in transient pipe flows

Applied mathematical modelling, 2022-11, Vol.111, p.454-470

2022

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Method of characteristics for transient, spherical flows

Applied Mathematical Modelling, 2020-01, Vol.77, p.810-828

2020

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Regulation of Histone mRNA in the Unperturbed Cell Cycle: Evidence Suggesting Control at Two Posttranscriptional Steps

Molecular and cellular biology, 1991-05, Vol.11 (5), p.2416-2424

1991

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Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

Nature metabolism, 2021-06, Vol.3 (6), p.762-773

2021

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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

Clinical cancer research, 2004-02, Vol.10 (3), p.881-889

2004

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Energy optimisation of pneumatic actuator systems in manufacturing

Journal of cleaner production, 2014-06, Vol.72, p.35-45

2014

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A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders

Nature Cardiovascular Research, 2024-02, Vol.3 (2), p.166-185

2024

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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O6-Substituted Guanine Derivatives

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Resistance-Modifying Agents. 8. Inhibition of O 6-Alkylguanine-DNA Alkyltransferase by O 6-Alkenyl-, O 6-Cycloalkenyl-, and O 6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O 6-(1-Cyclopentenylmethyl)guanine

N 2 -Substituted O 6 -Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives

Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine

N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O 6-Substituted Guanine Derivatives

Resistance-Modifying Agents. 8. Inhibition of O6-Alkylguanine-DNA Alkyltransferase by O6-Alkenyl-, O6-Cycloalkenyl-, and O6-(2-Oxoalkyl)guanines and Potentiation of Temozolomide Cytotoxicity in Vitro by O6-(1-Cyclopentenylmethyl)guanine

High HIV seroprevalence and increased HIV-associated mortality among hospitalized patients with deep bacterial infections in Dar es Salaam, Tanzania

Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFα

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines)

Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha

N2-Substituted O 6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

On Boussinesq and Coriolis coefficients and their derivatives in transient pipe flows

Method of characteristics for transient, spherical flows

Regulation of Histone mRNA in the Unperturbed Cell Cycle: Evidence Suggesting Control at Two Posttranscriptional Steps

Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

Energy optimisation of pneumatic actuator systems in manufacturing

A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders

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