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Structural Basis of Transcription Initiation

Science (American Association for the Advancement of Science), 2012-11, Vol.338 (6110), p.1076-1080

2012

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Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (15), p.7308-7313

2019

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Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery

Progress in biophysics and molecular biology, 2014-11, Vol.116 (2-3), p.92-100

2014

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Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Journal of molecular biology, 2009-01, Vol.385 (3), p.693-713

2009

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Epistasis and entrenchment of drug resistance in HIV-1 subtype B

eLife, 2019-10, Vol.8

2019

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Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV

Pharmaceuticals (Basel, Switzerland), 2020-06, Vol.13 (6), p.122

2020

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Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

Journal of virology, 2018-07, Vol.92 (13)

2018

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Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

Scientific reports, 2018-03, Vol.8 (1), p.5016-12, Article 5016

2018

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Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase

Nucleic acids research, 2020-03, Vol.48 (5), p.2709

2020

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (5), p.1466-1471

2008

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Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

Nature chemistry, 2013-03, Vol.5 (3), p.174

2013

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Structural basis for suppression of a host antiviral response by influenza A virus

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (35), p.13093-13098

2008

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Structure of HIV‐1 reverse transcriptase bound to a novel 38‐mer hairpin template‐primer DNA aptamer

Protein science, 2016-01, Vol.25 (1), p.46-55

2016

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The RNA Polymerase “Switch Region” Is a Target for Inhibitors

Cell, 2008-10, Vol.135 (2), p.295-307

2008

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Conformational States of HIV‑1 Reverse Transcriptase for Nucleotide Incorporation vs PyrophosphorolysisBinding of Foscarnet

ACS chemical biology, 2016-08, Vol.11 (8), p.2158-2164

2016

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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.3103

2023

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Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

The Journal of biological chemistry, 2004-08, Vol.279 (32), p.33946-33957

2004

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Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (5), p.1472-1477

2008

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Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Progress in biophysics and molecular biology, 2005-06, Vol.88 (2), p.209-231

2005

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Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

ACS chemical biology, 2013-11, Vol.8 (11), p.2501-2508

2013

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Structural basis of HIV-1 resistance to AZT by excision

Nature structural & molecular biology, 2010-10, Vol.17 (10), p.1202

2010

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Structural and Molecular Interactions of CCR5 Inhibitors with CCR5

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12688-12698

2006

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Co-crystallization with diabodies: A case study for the introduction of synthetic symmetry

Structure (London), 2021-06, Vol.29 (6), p.598-605.e3

2021

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Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

Viruses, 2021-07, Vol.13 (8), p.1495

2021

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HIV-1 reverse transcriptase and antiviral drug resistance. Part 1

Current opinion in virology, 2013-04, Vol.3 (2), p.111-118

2013

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Structural Basis of Transcription Initiation

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation

Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Epistasis and entrenchment of drug resistance in HIV-1 subtype B

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV

Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

Structural basis for suppression of a host antiviral response by influenza A virus

Structure of HIV‐1 reverse transcriptase bound to a novel 38‐mer hairpin template‐primer DNA aptamer

The RNA Polymerase “Switch Region” Is a Target for Inhibitors

Conformational States of HIV‑1 Reverse Transcriptase for Nucleotide Incorporation vs PyrophosphorolysisBinding of Foscarnet

Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

Structural basis of HIV-1 resistance to AZT by excision

Structural and Molecular Interactions of CCR5 Inhibitors with CCR5

Co-crystallization with diabodies: A case study for the introduction of synthetic symmetry

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

HIV-1 reverse transcriptase and antiviral drug resistance. Part 1

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