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Patient-derived tumour xenografts as models for oncology drug development

Nature reviews. Clinical oncology, 2012-06, Vol.9 (6), p.338-350

2012

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CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma

Cancer research (Chicago, Ill.), 2018-12, Vol.78 (23), p.6561-6574

2018

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Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

JNCI : Journal of the National Cancer Institute, 2017-01, Vol.109 (1), p.djw189

2017

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Targeting the WNT Signaling Pathway in Cancer Therapeutics

The oncologist (Dayton, Ohio), 2015-10, Vol.20 (10), p.1189-1198

2015

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Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer

PloS one, 2014-11, Vol.9 (11), p.e113037

2014

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Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

Oncotarget, 2017-08, Vol.8 (34), p.56051-56065

2017

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Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL)

PloS one, 2024-04, Vol.19 (4), p.e0298808-e0298808

2024

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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms

Molecular cancer therapeutics, 2018-10, Vol.17 (10), p.2112-2122

2018

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ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways

PloS one, 2015-05, Vol.10 (5), p.e0121648-e0121648

2015

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Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Clinical cancer research, 2013-08, Vol.19 (15), p.4149-4162

2013

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Association between IL-32 genotypes and outcome in infection-associated acute lung injury

Critical care (London, England), 2011-01, Vol.15 (3), p.R138-R138

2011

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Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation

The Journal of immunology (1950), 2000-09, Vol.165 (6), p.2950-2954

2000

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Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer

British journal of cancer, 2017-09, Vol.117 (10), p.1537-1543

2017

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Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

BMC cancer, 2018-02, Vol.18 (1), p.136-12, Article 136

2018

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Potent antitumor activity of cabozantinib, a c‐MET and VEGFR2 inhibitor, in a colorectal cancer patient‐derived tumor explant model

International journal of cancer, 2015-04, Vol.136 (8), p.1967-1975

2015

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Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury

American journal of physiology. Lung cellular and molecular physiology, 2000-12, Vol.279 (6), p.1137-L1145

2000

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Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model

PloS one, 2017-11, Vol.12 (11), p.e0187173-e0187173

2017

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A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer

International journal of cancer, 2016-01, Vol.138 (1), p.195-205

2016

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Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

Oncotarget, 2016-08, Vol.7 (31), p.50290-50301

2016

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Activation of gene expression in human neutrophils by high mobility group box 1 protein

American Journal of Physiology: Cell Physiology, 2003-04, Vol.284 (4), p.C870-C879

2003

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Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma

Pancreas, 2016-01, Vol.45 (1), p.117

2016

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Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models

Anti-cancer drugs, 2018-10, Vol.29 (9), p.827-838

2018

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The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

Oncotarget, 2016-05, Vol.7 (19), p.28273-28285

2016

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An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent

Marine drugs, 2014-09, Vol.12 (9), p.4833-4850

2014

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Patient-derived tumour xenografts as models for oncology drug development

CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

Targeting the WNT Signaling Pathway in Cancer Therapeutics

Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL)

Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms

ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Association between IL-32 genotypes and outcome in infection-associated acute lung injury

Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation

Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

Potent antitumor activity of cabozantinib, a c‐MET and VEGFR2 inhibitor, in a colorectal cancer patient‐derived tumor explant model

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury

Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model

A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer

Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

Activation of gene expression in human neutrophils by high mobility group box 1 protein

Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma

Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models

The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance

An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent

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