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Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

Neuropharmacology, 2013-03, Vol.66, p.202-214

2013

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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant

British journal of pharmacology, 2009-05, Vol.157 (2), p.307-319

2009

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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant

British journal of pharmacology, 2009-05, Vol.157 (2), p.307-319

2009

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New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4235-4256

1997

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Differential Effect of Subchronic Treatment with Various Neuroleptic Agents on Serotonin2 Receptors in Rat Cerebral Cortex

Journal of neurochemistry, 1986-01, Vol.46 (1), p.191-197

1986

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Biochemical and electrophysiological studies of the psychotropic compound, amperozide

Brain research bulletin, 1987-10, Vol.19 (4), p.465-471

1987

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Studies towards the next generation of antidepressants. Part 1 : Indolylcyclohexylamines as potent serotonin reuptake inhibitors

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1885-1888

2001

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Antipsychotic activity of substituted .gamma.-carbolines

Journal of medicinal chemistry, 1987-10, Vol.30 (10), p.1818-1823

1987

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New Generation Dopaminergic Agents. 6. Structure−Activity Relationship Studies of a Series of 4-(Aminoethoxy)indole and 4-(Aminoethoxy)indolone Derivatives Based on the Newly Discovered 3-Hydroxyphenoxyethylamine D2 Template

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.2007-2020

1999

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Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxine

Drug development research, 1991, Vol.23 (2), p.191-199

1991

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New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

Bioorganic & medicinal chemistry letters, 1999-09, Vol.9 (17), p.2593-2598

1999

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1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1069-1071

2001

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Evidence for cholinergic muscarinic receptors on mediodorsal thalamic projections to the anterior cingulate cortex

Neuroscience letters, 1983-09, Vol.40 (2), p.99-103

1983

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Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain

The Journal of pharmacology and experimental therapeutics, 2007-03, Vol.320 (3), p.1178

2007

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Preclinical profile of the pyrimidinylpiperazinyl imide compound WY-47,846: A potential anxiolytic

Drug development research, 1989, Vol.18 (1), p.29-45

1989

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Characteristics of Rat Skull Benzylamine Oxidase

Proceedings of the Society for Experimental Biology and Medicine, 1982-12, Vol.171 (3), p.298-305

1982

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Phosphorus analogs of .gamma.-aminobutyric acid, a new class of anticonvulsants

Journal of medicinal chemistry, 1984-05, Vol.27 (5), p.654-659

1984

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New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Bioorganic & medicinal chemistry letters, 1998-02, Vol.8 (3), p.295-300

1998

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Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1382-1392

1988

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Neurochemical effects of kojic amine, a gabamimetic, and its interaction with benzylamine oxidase

Neuropharmacology, 1981-12, Vol.20 (12), p.1177-1182

1981

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The inhibition of glycogen synthase kinase 3β by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aβ peptides

Journal of neurochemistry, 2005-12, Vol.95 (5), p.1363-1372

2005

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Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3823-3842

2004

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Studies toward the discovery of the next generation of antidepressants. Part 5 : 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1338-1341

2006

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The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices

European journal of pharmacology, 2006-05, Vol.536 (3), p.262-268

2006

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Effect of subchronic treatment with neuroleptic, imipramine, and the combination on serotonin receptor binding in rat cerebral cortex

Psychopharmacology bulletin, 1984, Vol.20 (3), p.349

1984

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Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant

Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant

New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. Structure−Activity Relationships of a Series of 2-(Aminomethyl)chromans

Differential Effect of Subchronic Treatment with Various Neuroleptic Agents on Serotonin2 Receptors in Rat Cerebral Cortex

Biochemical and electrophysiological studies of the psychotropic compound, amperozide

Studies towards the next generation of antidepressants. Part 1 : Indolylcyclohexylamines as potent serotonin reuptake inhibitors

Antipsychotic activity of substituted .gamma.-carbolines

New Generation Dopaminergic Agents. 6. Structure−Activity Relationship Studies of a Series of 4-(Aminoethoxy)indole and 4-(Aminoethoxy)indolone Derivatives Based on the Newly Discovered 3-Hydroxyphenoxyethylamine D2 Template

Biochemical, neurophysiological, and behavioral effects of Wy-45,233 and other identified metabolites of the antidepressant venlafaxine

New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template

1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors

Evidence for cholinergic muscarinic receptors on mediodorsal thalamic projections to the anterior cingulate cortex

Differential and synergistic effects of selective norepinephrine and serotonin reuptake inhibitors in rodent models of pain

Preclinical profile of the pyrimidinylpiperazinyl imide compound WY-47,846: A potential anxiolytic

Characteristics of Rat Skull Benzylamine Oxidase

Phosphorus analogs of .gamma.-aminobutyric acid, a new class of anticonvulsants

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH- N1-phenylpiperazine dopaminergic templates

Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies

Neurochemical effects of kojic amine, a gabamimetic, and its interaction with benzylamine oxidase

The inhibition of glycogen synthase kinase 3β by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aβ peptides

Studies toward the Discovery of the Next Generation of Antidepressants. 3. Dual 5-HT1A and Serotonin Transporter Affinity within a Class of N-Aryloxyethylindolylalkylamines

Studies toward the discovery of the next generation of antidepressants. Part 5 : 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices

Effect of subchronic treatment with neuroleptic, imipramine, and the combination on serotonin receptor binding in rat cerebral cortex

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