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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Journal of Virology, 2012-11, Vol.86 (21), p.11754-11762

2012

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Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

Bioorganic & medicinal chemistry, 2010-02, Vol.18 (3), p.1093-1102

2010

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Neutrophil elastase inhibitors

Expert opinion on therapeutic patents, 2011-03, Vol.21 (3), p.339-354

2011

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Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure–Activity Relationships and Biochemical, X‑ray Crystallographic, Cell-Based, and In Vivo Studies

Journal of medicinal chemistry, 2015-04, Vol.58 (7), p.3144-3155

2015

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Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases

Bioorganic & medicinal chemistry, 2013-01, Vol.21 (1), p.102-113

2013

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Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6317-6320

2013

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Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (3), p.1213-1221

2012

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Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

European journal of medicinal chemistry, 2016-08, Vol.119, p.300-318

2016

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Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.1899-1913

2016

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Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.6239-6248

2017

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Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold

Bioorganic & medicinal chemistry, 2012-07, Vol.20 (13), p.4140-4148

2012

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Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (13), p.3709-3712

2013

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Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4820-4826

2012

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Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.62-65

2013

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Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5315-5319

2011

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Cyclosulfamide-based derivatives as inhibitors of noroviruses

European journal of medicinal chemistry, 2012-01, Vol.47 (1), p.59-64

2012

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Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (21), p.5941-5944

2013

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Design and synthesis of inhibitors of noroviruses by scaffold hopping

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (19), p.5749-5755

2011

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Potent norovirus inhibitors based on the acyclic sulfamide scaffold

Bioorganic & medicinal chemistry, 2012-03, Vol.20 (6), p.2111-2118

2012

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Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (20), p.5975-5983

2011

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Dual function inhibitors of relevance to chronic obstructive pulmonary disease

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3177-3180

2011

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Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

European journal of medicinal chemistry, 2010-09, Vol.45 (9), p.4280-4287

2010

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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2003-2008

2008

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Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides

Bioorganic & medicinal chemistry, 2008-01, Vol.16 (2), p.692-698

2008

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Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents

Archives of biochemistry and biophysics, 2008-07, Vol.475 (2), p.115-120

2008

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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3

Neutrophil elastase inhibitors

Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure–Activity Relationships and Biochemical, X‑ray Crystallographic, Cell-Based, and In Vivo Studies

Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease

Inhibitors of Dengue virus and West Nile virus proteases based on the aminobenzamide scaffold

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease

Cyclosulfamide-based derivatives as inhibitors of noroviruses

Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

Design and synthesis of inhibitors of noroviruses by scaffold hopping

Potent norovirus inhibitors based on the acyclic sulfamide scaffold

Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

Dual function inhibitors of relevance to chronic obstructive pulmonary disease

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives

Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides

Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents

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