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HTS approaches to voltage-gated ion channel drug discovery

Drug Discovery Today, 1998-07, Vol.3 (7), p.323-332

1998

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Bioengineered 3D Glial Cell Culture Systems and Applications for Neurodegeneration and Neuroinflammation

SLAS Discovery, 2017-06, Vol.22 (5), p.583-601

2017

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The Growing Gap Between Emerging Technologies and Legal-Ethical Oversight: The Pacing Problem

1, 2011

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Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells

Blood, 1997-08, Vol.90 (3), p.1175-1185

1997

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Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.492-496

2011

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Effect of Vitamin A Deficiency on the Expression of Low Affinity Glucocorticoid Binding Site Activity and Glucocorticoid-Dependent Induction of CYP3A2 in Rat Liver

Biochemical and biophysical research communications, 1997-08, Vol.237 (2), p.211-216

1997

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Retinoic Acid Receptors and Retinoid X Receptors: Interactions with Endogenous Retinoic Acids

Proceedings of the National Academy of Sciences - PNAS, 1993-01, Vol.90 (1), p.30-34

1993

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9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

Nature (London), 1992-01, Vol.355 (6358), p.359-361

1992

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Identification of iNOS Inhibitors Using InteraX

Journal of biomolecular screening, 2009-03, Vol.14 (3), p.263-272

2009

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Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid

The Journal of biological chemistry, 1994-06, Vol.269 (24), p.16689-16695

1994

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The Ying-yang of RAR and AP-1: cancer treatment without overt toxicity: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Xian-Ping L & Pfahl M. Nature, 372 107—111

Human & experimental toxicology, 1995-02, Vol.14 (2), p.226-230

Allenby, Gary

1995

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New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid

Molecular and Cellular Biology, 1995-10, Vol.15 (10), p.5226-5234

1995

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Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in vivo and in vitro studies

Endocrinology (Philadelphia), 1991-01, Vol.128 (1), p.467-476

1991

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Characterization of the Retinoid Binding Properties of the Major Fusion Products Present in Acute Promyelocytic Leukemia Cells

Blood, 1997-08, Vol.90 (3), p.1175-1185

1997

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Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha

Molecular and Cellular Biology, 1994-04, Vol.14 (4), p.2323-2330

1994

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A systematic analysis of the AF‐2 domain of human retinoic acid receptor α reveals amino acids critical for transcriptional activation and conformational integrity

The FASEB journal, 1996-11, Vol.10 (13), p.1524-1531

1996

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Evaluation of Changes in the Secretion of Immunoactive Inhibin by Adult Rat Seminiferous Tubules in Vitro as an Indicator of Early Toxicant Action on Spermatogenesis

Toxicological sciences, 1991, Vol.16 (4), p.710-724

1991

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Chemical disruption of spermatogenesis

Allenby, Gary

1990

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Changes in Sertoli Cell Function in vitro Induced by Nitrobenzene

Toxicological sciences, 1990-02, Vol.14 (2), p.364-375

1990

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A new pathway for vitamin A: understanding the pleiotropic effects of retinoids

Annals of the New York Academy of Sciences, 1992-09, Vol.669 (1), p.70-85

1992

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A New Pathway for Vitamin A

Annals of the New York Academy of Sciences, 1992-09, Vol.669 (1), p.70-85

1992

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Automated High Throughput Screening of Fluorescent Imaging Plate Reader (FLIPR) Assays Using Assay Platform™ Integrated with Activity Base for ‘on the fly’ Compound Reconfirmation

Journal of Laboratory Automation, 2001-10, Vol.6 (5), p.48-50

2001

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Distinct Binding Determinants for 9-cis Retinoic Acid Are Located within AF-2 of Retinoic Acid Receptor α

Molecular and cellular biology, 1994-04, Vol.14 (4), p.2323-2330

1994

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Changes in sertoli cell function in vitro induced by nitrobenzene

Fundamental and applied toxicology, 1990, Vol.14 (2), p.364-375

1990

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Evaluation of changes in the secretion of immunoactive inhibin by adult rat seminiferous tubules in vitro as an indicator of early toxicant action on spermatogenesis

Fundamental and applied toxicology, 1991-05, Vol.16 (4), p.710-724

1991

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HTS approaches to voltage-gated ion channel drug discovery

Bioengineered 3D Glial Cell Culture Systems and Applications for Neurodegeneration and Neuroinflammation

The Growing Gap Between Emerging Technologies and Legal-Ethical Oversight: The Pacing Problem

Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

Effect of Vitamin A Deficiency on the Expression of Low Affinity Glucocorticoid Binding Site Activity and Glucocorticoid-Dependent Induction of CYP3A2 in Rat Liver

Retinoic Acid Receptors and Retinoid X Receptors: Interactions with Endogenous Retinoic Acids

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

Identification of iNOS Inhibitors Using InteraX

Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid

The Ying-yang of RAR and AP-1: cancer treatment without overt toxicity: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Xian-Ping L & Pfahl M. Nature, 372 107—111

New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid

Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in vivo and in vitro studies

Characterization of the Retinoid Binding Properties of the Major Fusion Products Present in Acute Promyelocytic Leukemia Cells

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha

A systematic analysis of the AF‐2 domain of human retinoic acid receptor α reveals amino acids critical for transcriptional activation and conformational integrity

Evaluation of Changes in the Secretion of Immunoactive Inhibin by Adult Rat Seminiferous Tubules in Vitro as an Indicator of Early Toxicant Action on Spermatogenesis

Chemical disruption of spermatogenesis

Changes in Sertoli Cell Function in vitro Induced by Nitrobenzene

A new pathway for vitamin A: understanding the pleiotropic effects of retinoids

A New Pathway for Vitamin A

Automated High Throughput Screening of Fluorescent Imaging Plate Reader (FLIPR) Assays Using Assay Platform™ Integrated with Activity Base for ‘on the fly’ Compound Reconfirmation

Distinct Binding Determinants for 9-cis Retinoic Acid Are Located within AF-2 of Retinoic Acid Receptor α

Changes in sertoli cell function in vitro induced by nitrobenzene

Evaluation of changes in the secretion of immunoactive inhibin by adult rat seminiferous tubules in vitro as an indicator of early toxicant action on spermatogenesis

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