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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

Journal of medicinal chemistry, 1986-05, Vol.29 (5), p.849-852

1986

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Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits

The Journal of pharmacology and experimental therapeutics, 1989-02, Vol.248 (2), p.498

1989

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Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent

Proceedings of the National Academy of Sciences - PNAS, 1980-07, Vol.77 (7), p.3957-3961

1980

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On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors

Experimental eye research, 1990, Vol.50 (1), p.65-78

1990

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Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by β-lactone inhibitors and binding of these inhibitors to the enzyme

Biochemical journal, 1993-02, Vol.289 (3), p.889-895

1993

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Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor

The Journal of pharmacology and experimental therapeutics, 1988-08, Vol.246 (2), p.534

1988

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Hydroxymethylglutaryl-coenzyme A Reductase-Containing Hepatocytes are Distributed Periportally in Normal and Mevinolin-Treated Rat Livers

Proceedings of the National Academy of Sciences - PNAS, 1984-09, Vol.81 (17), p.5556-5560

1984

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Discovery, biochemistry and biology of lovastatin

The American journal of cardiology, 1988-11, Vol.62 (15), p.J10-J15

Alberts, Alfred W.

1988

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Inhibition of Hydroxymethylglutaryl-Coenzyme A Synthase by L-659,699

Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (21), p.7488-7492

1987

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Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin

European journal of clinical pharmacology, 1991, Vol.40 (1), p.S11-S14

1991

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted-[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives

Journal of medicinal chemistry, 1986-02, Vol.29 (2), p.170-181

1986

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Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3474-3482

1992

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogs of lovastatin

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2474-2477

1991

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(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

Biochemical and biophysical research communications, 1988-02, Vol.150 (3), p.1213-1220

1988

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Plasma mevalonate as a measure of cholesterol synthesis in man

The Journal of clinical investigation, 1984-09, Vol.74 (3), p.795-804

1984

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Metabolism of lovastatin by rat and human liver microsomes in vitro

Drug metabolism and disposition, 1988-09, Vol.16 (5), p.678

1988

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives

Journal of medicinal chemistry, 1986-02, Vol.29 (2), p.159-169

1986

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Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

The American journal of pathology, 1988-09, Vol.132 (3), p.427-443

1988

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidene)-3,5-dihydroxyhexanoic acids and their lactone derivatives

Journal of medicinal chemistry, 1986-05, Vol.29 (5), p.852-855

1986

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Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

Biochemical and biophysical research communications, 1989-02, Vol.158 (3), p.667-675

1989

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Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet

The Journal of biological chemistry, 1982-04, Vol.257 (7), p.3623-3627

1982

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Characterization of an Endopeptidase Involved in Pre-Protein Processing

Proceedings of the National Academy of Sciences - PNAS, 1979-09, Vol.76 (9), p.4225-4229

1979

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Intestinal and hepatic cholesterogenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs

Diabetes (New York, N.Y.), 1991-12, Vol.40 (12), p.1630-1639

1991

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Phenobarbital induces rat liver apolipoprotein A-I mRNA

Molecular pharmacology, 1985-03, Vol.27 (3), p.394-398

1985

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3813-3821

1992

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits

Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent

On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors

Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by β-lactone inhibitors and binding of these inhibitors to the enzyme

Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor

Hydroxymethylglutaryl-coenzyme A Reductase-Containing Hepatocytes are Distributed Periportally in Normal and Mevinolin-Treated Rat Livers

Discovery, biochemistry and biology of lovastatin

Inhibition of Hydroxymethylglutaryl-Coenzyme A Synthase by L-659,699

Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 3. 7-(3,5-Disubstituted-[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives

Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogs of lovastatin

(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

Plasma mevalonate as a measure of cholesterol synthesis in man

Metabolism of lovastatin by rat and human liver microsomes in vitro

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives

Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidene)-3,5-dihydroxyhexanoic acids and their lactone derivatives

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet

Characterization of an Endopeptidase Involved in Pre-Protein Processing

Intestinal and hepatic cholesterogenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs

Phenobarbital induces rat liver apolipoprotein A-I mRNA

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

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