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Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers

Shock (Augusta, Ga.), 2019-10, Vol.52 (1S Suppl 1), p.41-49

Alayash, Abdu I

2019

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Blood substitutes: why haven’t we been more successful?

Trends in biotechnology (Regular ed.), 2014-04, Vol.32 (4), p.177-185

Alayash, Abdu I

2014

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βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease

Laboratory investigation, 2021-01, Vol.101 (1), p.4-11

Alayash, Abdu I.

2021

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Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy

Haematologica (Roma), 2021-01, Vol.106 (1), p.9-11

Alayash, Abdu I.

2021

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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Blood, 2013-02, Vol.121 (8), p.1276-1284

2013

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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Blood, 2014-01, Vol.123 (3), p.377-390

2014

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The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective

Frontiers in physiology, 2021-09, Vol.12, p.711976-711976

Alayash, Abdu I.

2021

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Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells

International journal of molecular sciences, 2021-08, Vol.22 (16), p.9041

2021

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Oxidation reactions of cellular and acellular hemoglobins: Implications for human health

Frontiers in medical technology, 2022-11, Vol.4, p.1068972-1068972

Alayash, Abdu I

2022

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Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease

Scientific reports, 2020-08, Vol.10 (1), p.14218-14218, Article 14218

2020

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Hemoglobin Oxidation Reactions in Stored Blood

Antioxidants, 2022-04, Vol.11 (4), p.747

Alayash, Abdu I

2022

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The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells

International journal of molecular sciences, 2020-12, Vol.21 (24), p.9453

2020

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Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Biomolecules (Basel, Switzerland), 2017-01, Vol.7 (1), p.2

Alayash, Abdu I

2017

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Impact of cold storage on the oxygenation and oxidation reactions of red blood cells

Frontiers in physiology, 2024-08, Vol.15, p.1427094

2024

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HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters

International journal of molecular sciences, 2022-12, Vol.24 (1), p.558

2022

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Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model

Frontiers in physiology, 2023-10, Vol.14, p.1278763-1278763

2023

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Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin

Frontiers in physiology, 2019-07, Vol.10, p.931-931

2019

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Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase‐1

FEBS open bio, 2016-09, Vol.6 (9), p.876-884

2016

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Hemoglobin can Act as a (Pseudo)-Peroxidase in Vivo. What is the Evidence?

Frontiers in molecular biosciences, 2022-06, Vol.9, p.910795-910795

2022

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Caffeic acid: an antioxidant with novel antisickling properties

FEBS open bio, 2021-12, Vol.11 (12), p.3293-3303

2021

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Molecular controls of the oxygenation and redox reactions of hemoglobin

Antioxidants & redox signaling, 2013-06, Vol.18 (17), p.2298-2313

2013

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Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Blood, 2009-03, Vol.113 (11), p.2578-2586

2009

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Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

The Journal of clinical investigation, 2009-08, Vol.119 (8), p.2271-2280

2009

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Oxidative pathways in the sickle cell and beyond

Blood cells, molecules, & diseases, 2018-05, Vol.70, p.78-86

Alayash, Abdu I.

2018

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CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Blood, 2006-01, Vol.107 (1), p.373-380

2006

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Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers

Blood substitutes: why haven’t we been more successful?

βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease

Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective

Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells

Oxidation reactions of cellular and acellular hemoglobins: Implications for human health

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease

Hemoglobin Oxidation Reactions in Stored Blood

The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells

Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Impact of cold storage on the oxygenation and oxidation reactions of red blood cells

HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters

Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model

Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin

Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase‐1

Hemoglobin can Act as a (Pseudo)-Peroxidase in Vivo. What is the Evidence?

Caffeic acid: an antioxidant with novel antisickling properties

Molecular controls of the oxygenation and redox reactions of hemoglobin

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

Oxidative pathways in the sickle cell and beyond

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

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