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Hit and lead generation: beyond high-throughput screening

Nature reviews. Drug discovery, 2003-05, Vol.2 (5), p.369-378

2003

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Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1704-1708

2014

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Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

European Journal of Organic Chemistry, 2012-01, Vol.2012 (1), p.47-52

2012

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Neighborhood-Preserving Visualization of Adaptive Structure-Activity Landscapes: Application to Drug Discovery

Angewandte Chemie International Edition, 2011-12, Vol.50 (49), p.11633-11636

International ed. in English, 2011

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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.137-142

2002

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A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Chembiochem : a European journal of chemical biology, 2002-05, Vol.3 (5), p.455-459

2002

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Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model

Organic & biomolecular chemistry, 2013-04, Vol.11 (15), p.2514-2533

2013

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Neighborhood‐Preserving Visualization of Adaptive Structure–Activity Landscapes: Application to Drug Discovery

Angewandte Chemie, 2011-12, Vol.123 (49), p.11837-11840

2011

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An Ireland-Claisen Rearrangement/Lactonisation Cascade as a Key Step in Studies Towards the Synthesis of (-)-Euonyminol

Synlett, 2011-11, Vol.2011 (18), p.2693-2696

2011

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Lead generation--enhancing the success of drug discovery by investing in the hit to lead process

Combinatorial chemistry & high throughput screening, 2003-02, Vol.6 (1), p.51-66

2003

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Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter

Nature (London), 2024-07, Vol.631 (8022), p.E17-E17

2024

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Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1452

International ed. in English, 2014

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Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1452-1452

2014

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Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors

Angewandte Chemie International Edition, 2014-02, Vol.53 (6), p.1704

International ed. in English, 2014

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Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von [beta]-Sekretase(BACE1)-Hemmern

Angewandte Chemie, 2014-02, Vol.126 (6), p.1730

2014

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Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern

Angewandte Chemie, 2014-02, Vol.126 (6), p.1730-1735

2014

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Innentitelbild: Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern (Angew. Chem. 6/2014)

Angewandte Chemie, 2014-02, Vol.126 (6), p.1476-1476

2014

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Optimising brain penetration

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.262-266

2008

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Towards the enantioselective synthesis of (−)-euonyminol - preparation of a fully functionalised lower-rim modelElectronic supplementary information (ESI) available: Crystallographic analysis for compounds 6, 17, 18c, 28a and 31 including CIF files and NMR spectra for all new compounds. CCDC 905361-905365. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3ob27187k

2013-03

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Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

Tetrahedron letters, 2002-10, Vol.43 (43), p.7687-7690

2002

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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Structure-activity relationship elucidation

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.256-261

2008

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Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.817-821

2004

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Hit and lead generation: beyond high-throughput screening

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

Neighborhood-Preserving Visualization of Adaptive Structure-Activity Landscapes: Application to Drug Discovery

Selective GlyT1 Inhibitors: Discovery of [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a Promising Novel Medicine To Treat Schizophrenia

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

A Virtual Screening Method for Prediction of the hERG Potassium Channel Liability of Compound Libraries

Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model

Neighborhood‐Preserving Visualization of Adaptive Structure–Activity Landscapes: Application to Drug Discovery

An Ireland-Claisen Rearrangement/Lactonisation Cascade as a Key Step in Studies Towards the Synthesis of (-)-Euonyminol

A novel antibiotic class targeting the lipopolysaccharide transporter

Lead generation--enhancing the success of drug discovery by investing in the hit to lead process

Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter

Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of [beta]-Secretase (BACE1) Inhibitors

Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von [beta]-Sekretase(BACE1)-Hemmern

Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern

Innentitelbild: Nahtlose Integration von Dosis-Wirkungs-basiertem Screening und Flusschemie: effiziente Erzeugung von Struktur-Aktivitäts-Beziehungen von β-Sekretase(BACE1)-Hemmern (Angew. Chem. 6/2014)

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Optimising brain penetration

Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands : Structure-activity relationship elucidation

Synthesis and SAR evaluation of 1,2,4-triazoles as A2A receptor antagonists

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