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Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

European journal of medicinal chemistry, 2018-03, Vol.148, p.453-464

2018

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Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

European journal of organic chemistry, 2015-02, Vol.2015 (5), p.978-986

2015

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Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

ACS medicinal chemistry letters, 2014-03, Vol.5 (3), p.249-254

2014

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Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1790-1801

2014

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Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Bioorganic & medicinal chemistry, 2016-06, Vol.24 (12), p.2603-2620

2016

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Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Bioorganic & medicinal chemistry, 2014-12, Vol.22 (23), p.6595-6615

2014

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Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals

Bioorganic & medicinal chemistry, 2003-06, Vol.11 (12), p.2551-2568

2003

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Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Journal of enzyme inhibition and medicinal chemistry, 2007-01, Vol.22 (2), p.191-199

2007

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Evaluation of a diverse set of potential P 1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (12), p.4057-4068

2007

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Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

The FEBS journal, 2007-11, Vol.274 (22), p.5979-5986

2007

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Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (12), p.4057-4068

2007

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P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Bioorganic & medicinal chemistry, 2011-08, Vol.19 (16), p.4917-4927

2011

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Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (14), p.5413-5424

2010

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Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (3), p.1448-1474

2007

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Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Bioorganic & medicinal chemistry, 2006-01, Vol.14 (2), p.544-559

2006

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Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety

Bioorganic & medicinal chemistry, 2008-03, Vol.16 (6), p.2955-2967

2008

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Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P 1 moiety

Bioorganic & medicinal chemistry, 2008-03, Vol.16 (6), p.2955-2967

2008

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Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Antiviral therapy, 2010-01, Vol.15 (6), p.841-852

2010

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Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

Antiviral therapy, 2007-01, Vol.12 (5), p.733-740

2007

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Tetrapeptides as potent protease inhibitors of hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase)

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3915-3922

2002

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Structure–activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Biochimica et biophysica acta, 2004-04, Vol.1672 (1), p.51-59

2004

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Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.203-206

2001

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Monoclonal Antibody-Targeted Superantigens: A Different Class of Anti-Tumor Agents

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (20), p.9287-9291

1991

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Pan-NS3 protease inhibitors of hepatitis C virus based on an R 3 -elongated pyrazinone scaffold

European journal of medicinal chemistry, 2018-03, Vol.148, p.453

2018

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Nitrofurans with high renal excretion

Journal of medicinal chemistry, 1974-07, Vol.17 (7), p.756-758

Akerblom, Eva B

1974

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Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones

Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase): A comparative study of different C-terminals

Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

Evaluation of a diverse set of potential P 1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

P2–P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors

Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety

Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P 1 moiety

Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

Tetrapeptides as potent protease inhibitors of hepatitis C virus full-Length NS3 (Protease-Helicase/NTPase)

Structure–activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

Monoclonal Antibody-Targeted Superantigens: A Different Class of Anti-Tumor Agents

Pan-NS3 protease inhibitors of hepatitis C virus based on an R 3 -elongated pyrazinone scaffold

Nitrofurans with high renal excretion

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