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Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives

Progress in retinal and eye research, 2020-07, Vol.77, p.100827-100827, Article 100827

2020

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Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration

PloS one, 2017-05, Vol.12 (5), p.e0177224

2017

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Identification of circular RNAs hosted by the RPGR ORF15 genomic locus

RNA biology, 2023-12, Vol.20 (1), p.31-47

2023

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Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (6), p.1984-1984

2013

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Natural disease history of a canine model of oligogenic RPGRIP1-cone-rod dystrophy establishes variable effects of previously and newly mapped modifier loci

Human molecular genetics, 2023-06, Vol.32 (13), p.2139-2151

2023

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Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations

PloS one, 2014-03, Vol.9 (3), p.e90390-e90390

2014

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Formal commentary

PLoS genetics, 2020-11, Vol.16 (11), p.e1009059-e1009059

2020

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Bestrophinopathy: An RPE-photoreceptor interface disease

Progress in retinal and eye research, 2017-05, Vol.58, p.70-88

2017

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Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration

PloS one, 2013-12, Vol.8 (12), p.e85408-e85408

2013

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Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18111-18111

2014

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Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (6), p.2132-2137

2012

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Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis

Molecular therapy, 2021-08, Vol.29 (8), p.2456-2468

2021

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A digital atlas of the dog brain

PloS one, 2012-12, Vol.7 (12), p.e52140-e52140

2012

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Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (43), p.E5844-E5853

2015

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Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations

Cell death & disease, 2024-09, Vol.15 (9), p.682-10, Article 682

2024

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Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies

Mammalian genome, 2012-02, Vol.23 (1-2), p.40-61

2012

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Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1 -associated cone-rod dystrophy

Frontiers in cellular neuroscience, 2023-08, Vol.17, p.1226603

2023

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Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects

PloS one, 2013-10, Vol.8 (10), p.e75666-e75666

2013

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Photoreceptor function and structure in retinal degenerations caused by biallelic BEST1 mutations

Vision research (Oxford), 2023-02, Vol.203, p.108157-108157, Article 108157

2023

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A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness

PloS one, 2015-09, Vol.10 (9), p.e0137072-e0137072

2015

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Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa

PloS one, 2015-02, Vol.10 (2), p.e0115723

2015

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Remembering Alan M. Laties, MD, 1931-2021

Investigative ophthalmology & visual science, 2022-03, Vol.63 (3), p.19-19

Aguirre, Gustavo D

2022

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Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

Molecular therapy, 2005-12, Vol.12 (6), p.1072-1082

2005

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Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration

Scientific reports, 2021-01, Vol.11 (1), p.460-460, Article 460

2021

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Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives

Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration

Identification of circular RNAs hosted by the RPGR ORF15 genomic locus

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

Natural disease history of a canine model of oligogenic RPGRIP1-cone-rod dystrophy establishes variable effects of previously and newly mapped modifier loci

Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations

Formal commentary

Bestrophinopathy: An RPE-photoreceptor interface disease

Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis

A digital atlas of the dog brain

Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations

Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies

Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1 -associated cone-rod dystrophy

Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects

Photoreceptor function and structure in retinal degenerations caused by biallelic BEST1 mutations

A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa

Remembering Alan M. Laties, MD, 1931-2021

Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration

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