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Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases

Angewandte Chemie International Edition, 2017-10, Vol.56 (41), p.12765-12769

International ed. in English, 2017

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Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease

Molecules (Basel, Switzerland), 2016-05, Vol.21 (5), p.634

2016

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Targeting the RAS-dependent chemoresistance: The Warburg connection

Seminars in cancer biology, 2019-02, Vol.54, p.80-90

2019

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Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

European journal of medicinal chemistry, 2014-03, Vol.75, p.82-95

2014

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The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9967-9973

2016

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Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

European journal of medicinal chemistry, 2014-06, Vol.80, p.543-561

2014

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Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234

CNS neuroscience & therapeutics, 2014-06, Vol.20 (6), p.568-570

2014

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Epigenetics and environment: a complex relationship

Journal of applied physiology (1985), 2010-07, Vol.109 (1), p.243-251

2010

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PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.938-947

2014

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Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

Drug design, development and therapy, 2014-01, Vol.8 (default), p.1893-1910

2014

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N‑Methyl‑N‑((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)‑1H‑indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor

Journal of medicinal chemistry, 2014-12, Vol.57 (24), p.10455-10463

2014

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Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

ChemMedChem, 2016-06, Vol.11 (12), p.1318-1327

2016

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Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones

Monatshefte für Chemie, 2016-06, Vol.147 (6), p.1069-1079

2016

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Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

Oncotarget, 2016-07, Vol.7 (30), p.47954-47965

2016

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Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments

Chemical record, 2021-01, Vol.21 (1), p.162-174

2021

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Vitamin D and Wnt/β-catenin Pathway in Colon Cancer : Role and Regulation of DICKKOPF Genes

Anticancer research, 2008-09, Vol.28 (5A), p.2613-2623

2008

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Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease

Mini reviews in medicinal chemistry, 2015-01, Vol.15 (8), p.648

2015

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N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

Molecules (Basel, Switzerland), 2022-11, Vol.27 (21), p.7437

2022

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Jóvenes de película: genealogía y cine juvenil en Chile del siglo XX

Revista latinoamericana de ciencias sociales, niñez y juventud, 2024-05, Vol.22 (2), p.1-16

Aguilera-Ruiz, Oscar

2024

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Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6937-6943

2018

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Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2‑Ethynylbenzoates

Journal of organic chemistry, 2023-06, Vol.88 (11), p.7373-7380

2023

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Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy

Molecules (Basel, Switzerland), 2020-07, Vol.25 (14), p.3190

2020

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Diabetes‐mediated promotion of colon mucosa carcinogenesis is associated with mitochondrial dysfunction

Molecular oncology, 2019-09, Vol.13 (9), p.1887-1897

2019

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Molecular evidence of field cancerization initiated by diabetes in colon cancer patients

Molecular oncology, 2019-04, Vol.13 (4), p.857-872

2019

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Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

Molecular cancer, 2010-06, Vol.9 (1), p.170-170, Article 170

2010

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Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease

Targeting the RAS-dependent chemoresistance: The Warburg connection

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234

Epigenetics and environment: a complex relationship

PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

N‑Methyl‑N‑((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)‑1H‑indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments

Vitamin D and Wnt/β-catenin Pathway in Colon Cancer : Role and Regulation of DICKKOPF Genes

Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

Jóvenes de película: genealogía y cine juvenil en Chile del siglo XX

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2‑Ethynylbenzoates

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy

Diabetes‐mediated promotion of colon mucosa carcinogenesis is associated with mitochondrial dysfunction

Molecular evidence of field cancerization initiated by diabetes in colon cancer patients

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

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