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Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Neurochemistry international, 2011-11, Vol.59 (6), p.925-935

2011

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Cariprazine (RGH-188), a potent D 3/D 2 dopamine receptor partial agonist, binds to dopamine D 3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Neurochemistry international, 2011-11, Vol.59 (6), p.925-935

2011

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Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15

Naunyn-Schmiedeberg's archives of pharmacology, 2008-11, Vol.378 (5), p.529-539

2008

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Effects of RGH-237 [ N -{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D 3 Receptor Partial Agonist in Animal Models of Cocaine Abuse

The Journal of pharmacology and experimental therapeutics, 2007-03, Vol.320 (3), p.1268-1278

2007

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Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3859-3861

2003

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Multiple Fragment Docking and Linking in Primary and Secondary Pockets of Dopamine Receptors

ACS medicinal chemistry letters, 2014-09, Vol.5 (9), p.1010-1014

2014

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Cariprazine (RGH-188), a Dopamine D 3 Receptor-Preferring, D 3 /D 2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

The Journal of pharmacology and experimental therapeutics, 2010-04, Vol.333 (1), p.328-340

2010

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Design of novel multiple-acting ligands towards SERT and 5-HT sub(2C) receptors

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (9), p.2118-2122

2014

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ChemInform Abstract: Discovery of Cariprazine (RGH-188): A Novel Antipsychotic Acting on Dopamine D3/D2 Receptors

ChemInform, 2012-09, Vol.43 (39), p.no-no

2012

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Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors

Bioorganic & medicinal chemistry letters, 2014-05, Vol.24 (9), p.2118-2122

2014

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Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15

Naunyn-Schmiedeberg's archives of pharmacology, 2008-11, Vol.378 (5), p.515-528

2008

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Sensitive LC–MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine

Journal of pharmaceutical and biomedical analysis, 2008-09, Vol.48 (2), p.388-397

2008

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Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (10), p.3437-3440

2012

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Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse

The Journal of pharmacology and experimental therapeutics, 2007-03, Vol.320 (3), p.1268

2007

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ChemInform Abstract: Discovery of Cariprazine (RGH‐188): A Novel Antipsychotic Acting on Dopamine D 3 /D 2 Receptors

ChemInform, 2012-09, Vol.43 (39)

Agai‐Csongor, Eva

2012

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Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5340-5344

2007

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Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile

The Journal of pharmacology and experimental therapeutics, 2010-04, Vol.333 (1), p.328

2010

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Antioxidant Building Blocks I. The Unexpected C-Acetylation of 2,6-Di-tert-butylphenol with Isopropenyl Acetate

Collection of Czechoslovak chemical communications, 1996-08, Vol.61 (8), p.1244-1247

1996

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Benzocrown derivatives as ionophores for alkali cations, I synthesis of urethane- and urea-linked mono- and bis-crown ethers

Liebigs Annalen der Chemie, 1988-04, Vol.1988 (4), p.349-353

1988

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Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Cariprazine (RGH-188), a potent D 3/D 2 dopamine receptor partial agonist, binds to dopamine D 3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15

Effects of RGH-237 [ N -{4-[4-(3-Aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an Orally Active, Selective Dopamine D 3 Receptor Partial Agonist in Animal Models of Cocaine Abuse

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Multiple Fragment Docking and Linking in Primary and Secondary Pockets of Dopamine Receptors

Cariprazine (RGH-188), a Dopamine D 3 Receptor-Preferring, D 3 /D 2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

Design of novel multiple-acting ligands towards SERT and 5-HT sub(2C) receptors

ChemInform Abstract: Discovery of Cariprazine (RGH-188): A Novel Antipsychotic Acting on Dopamine D3/D2 Receptors

Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15

Sensitive LC–MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine

Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors

Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuse

ChemInform Abstract: Discovery of Cariprazine (RGH‐188): A Novel Antipsychotic Acting on Dopamine D 3 /D 2 Receptors

Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile

Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile

Antioxidant Building Blocks I. The Unexpected C-Acetylation of 2,6-Di-tert-butylphenol with Isopropenyl Acetate

Benzocrown derivatives as ionophores for alkali cations, I synthesis of urethane- and urea-linked mono- and bis-crown ethers

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