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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Journal of lipid research, 1997-02, Vol.38 (2), p.373-390

1997

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Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.483-498

2005

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A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Arteriosclerosis, thrombosis, and vascular biology, 2005-12, Vol.25 (12), p.2608-2614

2005

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Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

OncoTargets and therapy, 2016-01, Vol.9 (Issue 1), p.3223-3232

2016

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Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue

Journal of medicinal chemistry, 1988-09, Vol.31 (9), p.1805-1815

1988

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α-alkylation of serine with self-reproduction of the center of chirality

Tetrahedron letters, 1984, Vol.25 (24), p.2545-2548

1984

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Synthesis, conformation, and immunosuppressive activities of three analogs of cyclosporin A modified in the 1-position

Journal of medicinal chemistry, 1990-03, Vol.33 (3), p.999-1009

1990

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α-Alkylation of Amino Acids without Racemization. Preparation of Either (S)- or (R)-α-Methyldopa from (S)-Alanine

Helvetica chimica acta, 1985-02, Vol.68 (1), p.144-154

1985

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Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3354-3370

2003

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Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2083-2092

2003

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A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold

Helvetica chimica acta, 2005-04, Vol.88 (4), p.707-730

2005

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Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-Ray Crystal-Structure Analysis

Helvetica chimica acta, 2005-04, Vol.88 (4), p.731-750

2005

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Enantioselektive α-Alkylierung von Asparagin- und Glutaminsäure über die Dilithium-enolatocarboxylate von 2-[3-Benzoyl-2-(tert-butyl)-1-methyl-5-oxoimidazolidin-4-yl]essigsäure und 3-[3-Benzoyl-2-(tert-butyl)-1-methyl-5-oxoimidazolidin-4-yl]propionsäure

Helvetica chimica acta, 1985-09, Vol.68 (6), p.1507-1518

1985

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Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

Hypertension (Dallas, Tex. 1979), 2002-12, Vol.40 (6), p.840-846

2002

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A short synthesis of enantiomerically pure (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoic acid, the unusual C-9 amino acid found in the immunosuppressive peptide cyclosporine

Journal of organic chemistry, 1987-06, Vol.52 (13), p.2881-2886

1987

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Preparative-Scale, Facile Synthesis of (2R,4E)-2-Methyl-4-hexenal: A Key Intermediate of (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-methylamino-6-octenoic Acid (MeBmt)

Synthesis (Stuttgart), 1988, Vol.1988 (8), p.608-610

1988

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Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

Bioorganic & medicinal chemistry letters, 2002-07, Vol.12 (13), p.1727-1730

2002

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Stereoselektive Alkylierung an C(α) von serin, Glycerinsäure, threonin und Weinsäure über heterocyclisches Enolate mit exocyclischer Doppelbindung

Helvetica chimica acta, 1987, Vol.70 (4), p.1194-1216

1987

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α-Alkylation of threonine

Tetrahedron letters, 1983, Vol.24 (32), p.3311-3314

1983

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Enantromerenreine Synthesebausteine aus verzweigter Äpfelsäure

Liebigs Annalen der Chemie, 1983 (12), p.2114-2126

1983

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ChemInform Abstract: Overall Enantioselective α‐Alkylation of Aspartic and Glutamic Acid Through Dilithium Enolatocarboxylates of 2‐[3‐Benzoyl‐2‐(tert.‐butyl)‐1‐methyl‐5‐oxoimidazolidin‐4‐yl]acetic und 3‐[3‐Benzoyl‐2‐(tert.‐butyl)‐1‐methyl‐5‐oxoimidazolidin‐4‐yl]propionic Acld, Respectively

Chemischer Informationsdienst, 1985-12, Vol.16 (50)

1985

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ChemInform Abstract: α‐ALKYLATION OF SERINE WITH SELF‐REPRODUCTION OF THE CENTER OF CHIRALITY

Chemischer Informationsdienst, 1984-10, Vol.15 (41)

1984

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ChemInform Abstract: α‐ALKYLATION OF THREONINE

Chemischer Informationsdienst, 1983-12, Vol.14 (49)

1983

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ChemInform Abstract: Preparative‐Scale, Facile Synthesis of (2R,4E)‐2‐Methyl‐4‐hexenal (I): A Key Intermediate of (2S,3R,4R,6E)‐3‐Hydroxy‐4‐methyl‐2‐methylamino‐6‐octenoic Acid (MeBmt) (II)

ChemInform, 1988-12, Vol.19 (50), p.no-no

1988

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ChemInform Abstract: A Short Synthesis of Enantiomerically Pure (2S,3R,4R,6E)‐3‐Hydroxy‐4methyl‐2‐(methylamino)‐6‐octenoic Acid (I), the Unusual C‐9 Amino Acid Found in the Immunosuppressive Peptide Cyclosporine

ChemInform, 1988-01, Vol.19 (1), p.no-no

1988

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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue

α-alkylation of serine with self-reproduction of the center of chirality

Synthesis, conformation, and immunosuppressive activities of three analogs of cyclosporin A modified in the 1-position

α-Alkylation of Amino Acids without Racemization. Preparation of Either (S)- or (R)-α-Methyldopa from (S)-Alanine

Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold

Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-Ray Crystal-Structure Analysis

Enantioselektive α-Alkylierung von Asparagin- und Glutaminsäure über die Dilithium-enolatocarboxylate von 2-[3-Benzoyl-2-(tert-butyl)-1-methyl-5-oxoimidazolidin-4-yl]essigsäure und 3-[3-Benzoyl-2-(tert-butyl)-1-methyl-5-oxoimidazolidin-4-yl]propionsäure

Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

A short synthesis of enantiomerically pure (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoic acid, the unusual C-9 amino acid found in the immunosuppressive peptide cyclosporine

Preparative-Scale, Facile Synthesis of (2R,4E)-2-Methyl-4-hexenal: A Key Intermediate of (2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-methylamino-6-octenoic Acid (MeBmt)

Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

Stereoselektive Alkylierung an C(α) von serin, Glycerinsäure, threonin und Weinsäure über heterocyclisches Enolate mit exocyclischer Doppelbindung

α-Alkylation of threonine

Enantromerenreine Synthesebausteine aus verzweigter Äpfelsäure

ChemInform Abstract: α‐ALKYLATION OF SERINE WITH SELF‐REPRODUCTION OF THE CENTER OF CHIRALITY

ChemInform Abstract: α‐ALKYLATION OF THREONINE

ChemInform Abstract: Preparative‐Scale, Facile Synthesis of (2R,4E)‐2‐Methyl‐4‐hexenal (I): A Key Intermediate of (2S,3R,4R,6E)‐3‐Hydroxy‐4‐methyl‐2‐methylamino‐6‐octenoic Acid (MeBmt) (II)

ChemInform Abstract: A Short Synthesis of Enantiomerically Pure (2S,3R,4R,6E)‐3‐Hydroxy‐4methyl‐2‐(methylamino)‐6‐octenoic Acid (I), the Unusual C‐9 Amino Acid Found in the Immunosuppressive Peptide Cyclosporine

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