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The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy

Molecular cancer therapeutics, 2017-10, Vol.16 (10), p.2223-2233

2017

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BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis

Molecular cancer therapeutics, 2015-12, Vol.14 (12), p.2762-2772

2015

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BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Clinical cancer research, 2009-05, Vol.15 (9), p.3094-3102

2009

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BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Current biology, 2007-02, Vol.17 (4), p.316-322

2007

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Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia

The Journal of pharmacology and experimental therapeutics, 2015-03, Vol.352 (3), p.579-589

2015

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Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype

Oncogenesis (New York, NY), 2018-02, Vol.7 (2), p.21-11, Article 21

2018

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A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation

Molecular cancer therapeutics, 2016-03, Vol.15 (3), p.354-365

2016

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Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

Cancer research (Chicago, Ill.), 1993-10, Vol.53 (20), p.4754-4756

1993

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A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

Blood, 2011-10, Vol.118 (15), p.4159-4168

2011

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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2388-2398

2016

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HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

Nature (London), 1987-03, Vol.326 (6110), p.304-306

1987

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Identification of tumor antigens in renal cell carcinoma by serological proteome analysis

Proteomics (Weinheim), 2001-07, Vol.1 (7), p.890-898

2001

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Prognostic value of CD44 splice variant expression in ovarian cancer

Oncology, 1995-09, Vol.52 (5), p.400-406

1995

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Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head‐and‐neck cancer xenografts

International journal of cancer, 2002-05, Vol.99 (3), p.396-402

2002

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Identification and characterization of 9D7, a novel human protein overexpressed in renal cell carcinoma

International journal of cancer, 2002-01, Vol.97 (2), p.217-224

2002

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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1919-1919

2012

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Abstract 2344: Modeling 1st- and 2nd-line therapy of BRAF mutant melanoma using a novel BRAF inhibitor with DFG-out binding mode

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2344-2344

2013

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Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44

The Journal of experimental medicine, 1993-04, Vol.177 (4), p.897-904

1993

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Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae

Gene, 1988-06, Vol.66 (2), p.223-234

1988

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Antigenic Structure of Human Interferon {omega}1 (Interferon {alpha}II1): Comparison with Other Human Interferons

Journal of general virology, 1987-06, Vol.68 (6), p.1669-1676

Adolf, Gunther R

1987

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Monoclonal antibodies and enzyme immunoassays specific for human interferon (IFN) gw1: Evidence that IFN-ω1 is a component of human leukocyte IFN

Virology (New York, N.Y.), 1990-04, Vol.175 (2), p.410-417

Adolf, Günther R.

1990

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Characterization of a high-affinity monoclonal antibody specific for CD44v6 as candidate for immunotherapy of squamous cell carcinomas

Cancer Immunology, Immunotherapy, 1996-12, Vol.43 (4), p.245-253

1996

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Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein

DNA and cell biology, 1990-12, Vol.9 (10), p.705-715

1990

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Isolation and partial characterization of the human erythrocyte band 7 integral membrane protein

Biochimica et biophysica acta, 1991-06, Vol.1065 (2), p.195-202

1991

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A monoclonal antibody-based enzyme immunoassay for quantitation of human tumor necrosis factor binding protein I, a soluble fragment of the 60 kDa TNF receptor, in biological fluids

Journal of immunological methods, 1991-09, Vol.143 (1), p.127-136

1991

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The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia

Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype

A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression

A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies

Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

Identification of tumor antigens in renal cell carcinoma by serological proteome analysis

Prognostic value of CD44 splice variant expression in ovarian cancer

Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head‐and‐neck cancer xenografts

Identification and characterization of 9D7, a novel human protein overexpressed in renal cell carcinoma

Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases

Abstract 2344: Modeling 1st- and 2nd-line therapy of BRAF mutant melanoma using a novel BRAF inhibitor with DFG-out binding mode

Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44

Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae

Antigenic Structure of Human Interferon {omega}1 (Interferon {alpha}II1): Comparison with Other Human Interferons

Monoclonal antibodies and enzyme immunoassays specific for human interferon (IFN) gw1: Evidence that IFN-ω1 is a component of human leukocyte IFN

Characterization of a high-affinity monoclonal antibody specific for CD44v6 as candidate for immunotherapy of squamous cell carcinomas

Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein

Isolation and partial characterization of the human erythrocyte band 7 integral membrane protein

A monoclonal antibody-based enzyme immunoassay for quantitation of human tumor necrosis factor binding protein I, a soluble fragment of the 60 kDa TNF receptor, in biological fluids

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