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Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

Parasitology, 2018-02, Vol.145 (2), p.116-133

2018

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Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

PloS one, 2012-12, Vol.7 (12), p.e52951-e52951

2012

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DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

Nature communications, 2023-06, Vol.14 (1), p.3828-3828, Article 3828

2023

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Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

Scientific reports, 2017-08, Vol.7 (1), p.9430-15, Article 9430

2017

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In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae

ACS chemical biology, 2013-12, Vol.8 (12), p.2688-2696

2013

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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation

PloS one, 2015-03, Vol.10 (3), p.e0121492-e0121492

2015

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Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

PloS one, 2014-11, Vol.9 (11), p.e113568-e113568

2014

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Synthesis and recycling of the mycobacterial cell envelope

Current opinion in microbiology, 2021-04, Vol.60, p.58-65

2021

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Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

Cell surface (Amsterdam), 2020-12, Vol.6, p.100040-100040, Article 100040

2020

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Mycobacterial drug discovery

RSC medicinal chemistry, 2020-12, Vol.11 (12), p.1354-1365

2020

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Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

Chemistry : a European journal, 2017-05, Vol.23 (30), p.7207-7211

2017

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Assay development and inhibition of the Mt -DprE2 essential reductase from Mycobacterium tuberculosis

Microbiology (Society for General Microbiology), 2023-01, Vol.169 (1)

2023

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GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

Antimicrobial agents and chemotherapy, 2022-06, Vol.66 (6), p.e0013222-e0013222

2022

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Identification of KasA as the cellular target of an anti-tubercular scaffold

Nature communications, 2016-09, Vol.7 (1), p.12581-12581, Article 12581

2016

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Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Scientific reports, 2016-12, Vol.6 (1), p.38986-38986, Article 38986

2016

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Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

ACS infectious diseases, 2021-01, Vol.7 (1), p.141-152

2021

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THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Nature microbiology, 2016-01, Vol.1 (2), p.15006, Article 15006

2016

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Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

FASEB bioAdvances, 2019-04, Vol.1 (4), p.246-254

2019

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Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis: This article is part of the Diversity in Microbiology collection

Microbiology (Society for General Microbiology), 2023-01, Vol.169 (1)

2023

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Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation: e0121492

PloS one, 2015-03, Vol.10 (3)

2015

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Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target: e113568

PloS one, 2014-11, Vol.9 (11)

2014

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DRAQ5 and Eosin ('D&E') as an Analog to Hematoxylin and Eosin for Rapid Fluorescence Histology of Fresh Tissues

PloS one, 2016-10, Vol.11 (10), p.e0165530-e0165530

2016

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An Implantable Micro-Caged Device for Direct Local Delivery of Agents

Scientific reports, 2017-12, Vol.7 (1), p.17624-16, Article 17624

2017

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Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

Top five unanswered questions in bacterial cell wall research

In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target

Synthesis and recycling of the mycobacterial cell envelope

Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

Mycobacterial drug discovery

Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

Assay development and inhibition of the Mt -DprE2 essential reductase from Mycobacterium tuberculosis

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment

Identification of KasA as the cellular target of an anti-tubercular scaffold

Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis: This article is part of the Diversity in Microbiology collection

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation: e0121492

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target: e113568

DRAQ5 and Eosin ('D&E') as an Analog to Hematoxylin and Eosin for Rapid Fluorescence Histology of Fresh Tissues

An Implantable Micro-Caged Device for Direct Local Delivery of Agents

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