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Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Critical reviews in toxicology, 2024-02, Vol.54 (2), p.1-151

2024

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The need for good practice in the application of mechanistic constructs in hazard and risk assessment

Toxicological sciences, 2023-06, Vol.194 (1), p.13-22

2023

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A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

Food and chemical toxicology, 2022-07, Vol.165, p.113141, Article 113141

2022

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Towards a qAOP framework for predictive toxicology - Linking data to decisions

Computational toxicology, 2022-02, Vol.21, p.100195, Article 100195

2022

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Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Pharmacology & therapeutics (Oxford), 2017-11, Vol.179, p.84-95

2017

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Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

Critical reviews in toxicology, 2017-10, Vol.47 (9), p.733-753

2017

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AOPs in hazard characterization for human health

Current opinion in toxicology, 2017-04, Vol.3, p.80-86

Meek, M.E. (Bette)

2017

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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Neurotoxicology (Park Forest South), 2017-03, Vol.59, p.240-255

2017

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How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Toxicological sciences, 2017-02, Vol.155 (2), p.326-336

2017

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Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Journal of applied toxicology, 2016-09, Vol.36 (9), p.1077-1089

2016

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Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Environmental and molecular mutagenesis, 2015-12, Vol.56 (9), p.724-750

2015

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Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Toxicology (Amsterdam), 2015-06, Vol.332, p.112-123

2015

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Mode of Action/Human Relevance Framework

Hamilton & Hardy's Industrial Toxicology, 2015, p.2-3

6th Edition, 2015

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Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Journal of applied toxicology, 2014-11, Vol.34 (11), p.1115-1121

2014

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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Journal of applied toxicology, 2014-06, Vol.34 (6), p.595-606

2014

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Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

Critical reviews in toxicology, 2014-01, Vol.44 (1), p.1-49

2014

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International experience in addressing combined exposures: Increasing the efficiency of assessment

Toxicology (Amsterdam), 2013-11, Vol.313 (2-3), p.185-189

Meek, M.E. (Bette)

2013

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Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework

Toxicological sciences, 2013-11, Vol.136 (1), p.4-18

2013

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A framework for fit-for-purpose dose response assessment

Regulatory toxicology and pharmacology, 2013-07, Vol.66 (2), p.234-240

2013

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory toxicology and pharmacology, 2013-06, Vol.66 (1), p.116-129

2013

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Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

Regulatory toxicology and pharmacology, 2011-07, Vol.60 (2), p.S1-S14

2011

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Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Critical reviews in toxicology, 2011-03, Vol.41 (3), p.175-186

2011

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Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule

Critical reviews in toxicology, 2011-01, Vol.41 (1), p.1

2011

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Linear low-dose extrapolation for noncancer health effects is the exception, not the rule

Critical reviews in toxicology, 2011-01, Vol.41 (1), p.1-19

2011

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Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Chemico-biological interactions, 2010-03, Vol.184 (1), p.279-285

2010

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Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

The need for good practice in the application of mechanistic constructs in hazard and risk assessment

A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

Towards a qAOP framework for predictive toxicology - Linking data to decisions

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

AOPs in hazard characterization for human health

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Mode of Action/Human Relevance Framework

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

International experience in addressing combined exposures: Increasing the efficiency of assessment

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework

A framework for fit-for-purpose dose response assessment

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Linear low-dose extrapolation for noncancer heath effects is the exception, not the rule

Linear low-dose extrapolation for noncancer health effects is the exception, not the rule

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

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