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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Journal of applied toxicology, 2014-06, Vol.34 (6), p.595-606

2014

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A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

Critical reviews in toxicology, 2003-01, Vol.33 (6), p.591-653

2003

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How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Toxicological sciences, 2017-02, Vol.155 (2), p.326-336

2017

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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Neurotoxicology (Park Forest South), 2017-03, Vol.59, p.240-255

2017

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A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

Food and chemical toxicology, 2022-07, Vol.165, p.113141, Article 113141

2022

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Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

Critical reviews in toxicology, 2017-10, Vol.47 (9), p.733-753

2017

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4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.803-819

2006

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IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.781-792

2006

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Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Pharmacology & therapeutics (Oxford), 2017-11, Vol.179, p.84-95

2017

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A framework for fit-for-purpose dose response assessment

Regulatory toxicology and pharmacology, 2013-07, Vol.66 (2), p.234-240

2013

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Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Environmental and molecular mutagenesis, 2015-12, Vol.56 (9), p.724-750

2015

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The Human Relevance of Information on Carcinogenic Modes of Action: Overview

Critical reviews in toxicology, 2003-01, Vol.33 (6), p.581-589

2003

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Engaging Expert Peers in the Development of Risk Assessments

Risk analysis, 2007-12, Vol.27 (6), p.1609-1621

2007

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Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Critical reviews in toxicology, 2024-02, Vol.54 (2), p.134-151

2024

Volltextzugriff (PDF)

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Journal of applied toxicology, 2016-09, Vol.36 (9), p.1077-1089

2016

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Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Chemico-biological interactions, 2010-03, Vol.184 (1), p.279-285

2010

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Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Journal of applied toxicology, 2014-11, Vol.34 (11), p.1115-1121

2014

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory toxicology and pharmacology, 2013-06, Vol.66 (1), p.116-129

2013

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Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

Regulatory toxicology and pharmacology, 2011-07, Vol.60 (2), p.S1-S14

2011

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Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework

Toxicological sciences, 2013-11, Vol.136 (1), p.4-18

2013

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Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Toxicology (Amsterdam), 2015-06, Vol.332, p.112-123

2015

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International experience in addressing combined exposures: Increasing the efficiency of assessment

Toxicology (Amsterdam), 2013-11, Vol.313 (2-3), p.185-189

Meek, M.E. (Bette)

2013

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Towards a qAOP framework for predictive toxicology - Linking data to decisions

Computational toxicology, 2022-02, Vol.21, p.100195-100195, Article 100195

2022

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Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Critical reviews in toxicology, 2011-03, Vol.41 (3), p.175-186

2011

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Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

Environmental and molecular mutagenesis, 2008-03, Vol.49 (2), p.110-116

Meek, M.E. Bette

2008

Volltextzugriff (PDF)

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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

A framework for fit-for-purpose dose response assessment

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

The Human Relevance of Information on Carcinogenic Modes of Action: Overview

Engaging Expert Peers in the Development of Risk Assessments

Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

International experience in addressing combined exposures: Increasing the efficiency of assessment

Towards a qAOP framework for predictive toxicology - Linking data to decisions

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

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