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Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects

Toxicology letters, 2018-09, Vol.294, p.27-36

2018

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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13561-13577

2020

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Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6561-6574

2020

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Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity

Environmental pollution (1987), 2017-03, Vol.222, p.504-512

2017

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The metabolism and hepatotoxicity of ginkgolic acid (17 : 1) in vitro

Chinese journal of natural medicines, 2018-11, Vol.16 (11), p.829-837

2018

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Role of the CLOCK protein in liver detoxification

British journal of pharmacology, 2019-12, Vol.176 (24), p.4639-4652

2019

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In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol

Analytical and bioanalytical chemistry, 2015-07, Vol.407 (19), p.5803-5816

2015

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Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment

Antimicrobial agents and chemotherapy, 2016-09, Vol.60 (9), p.5285-5293

2016

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ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Nature chemical biology, 2021-08, Vol.17 (8), p.856-864

2021

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Metabolic transformation of cyclopiazonic acid in liver microsomes from different species based on UPLC-Q/TOF-MS

Journal of hazardous materials, 2024-09, Vol.476, p.134902, Article 134902

2024

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In vitro biotransformation of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate by mouse liver microsomes: Kinetics and key CYP isoforms

Chemosphere (Oxford), 2022-02, Vol.288 (Pt 1), p.132504-132504, Article 132504

2022

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In Vitro Liver Metabolism of Six Flavonoid C-Glycosides

Molecules (Basel, Switzerland), 2021-11, Vol.26 (21), p.6632

2021

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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.83-92

2012

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Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.92-99

2010

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Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1147-1158

2010

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Effects of the Thiol Methyltransferase Inhibitor (±)-2,3-Dichloro- α -Methylbenzylamine (DCMB) on the Pharmacokinetics and Metabolism of Vicagrel in Rats

Drug metabolism and disposition, 2024-08, Vol.52 (9), p.988-996

2024

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Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice

Food chemistry, 2013-11, Vol.141 (2), p.1063-1071

2013

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Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

Scientific reports, 2020-11, Vol.10 (1), p.19158, Article 19158

2020

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Dietary Polyphenols Inhibit the Cytochrome P450 Monooxygenase Branch of the Arachidonic Acid Cascade with Remarkable Structure-Dependent Selectivity and Potency

Journal of agricultural and food chemistry, 2020-08, Vol.68 (34), p.9235-9244

2020

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Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.8985-9003

2015

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Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation

Drug metabolism and disposition, 2024-06, Vol.52 (7), p.654

2024

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In vitro metabolic kinetics of cresyl diphenyl phosphate (CDP) in liver microsomes of crucian carp (Carassius carassius)

Environmental pollution (1987), 2021-04, Vol.274, p.116586, Article 116586

2021

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Screening of Protective Effect of Amifostine on Radiation-Induced Structural and Functional Variations in Rat Liver Microsomal Membranes by FT-IR Spectroscopy

Analytical chemistry (Washington), 2011-04, Vol.83 (7), p.2438-2444

2011

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Computationally Assessing the Bioactivation of Drugs by N‑Dealkylation

Chemical research in toxicology, 2018-02, Vol.31 (2), p.68-80

2018

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Identification of Optimal Urinary Biomarkers of Synthetic Cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID, and BZO-CHMOXIZID for Illicit Abuse Monitoring

Clinical chemistry (Baltimore, Md.), 2022-11, Vol.68 (11), p.1436-1448

2022

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Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity

The metabolism and hepatotoxicity of ginkgolic acid (17 : 1) in vitro

Role of the CLOCK protein in liver detoxification

In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol

Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

Metabolic transformation of cyclopiazonic acid in liver microsomes from different species based on UPLC-Q/TOF-MS

In vitro biotransformation of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate by mouse liver microsomes: Kinetics and key CYP isoforms

In Vitro Liver Metabolism of Six Flavonoid C-Glycosides

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data

Effects of the Thiol Methyltransferase Inhibitor (±)-2,3-Dichloro- α -Methylbenzylamine (DCMB) on the Pharmacokinetics and Metabolism of Vicagrel in Rats

Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

Dietary Polyphenols Inhibit the Cytochrome P450 Monooxygenase Branch of the Arachidonic Acid Cascade with Remarkable Structure-Dependent Selectivity and Potency

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation

In vitro metabolic kinetics of cresyl diphenyl phosphate (CDP) in liver microsomes of crucian carp (Carassius carassius)

Screening of Protective Effect of Amifostine on Radiation-Induced Structural and Functional Variations in Rat Liver Microsomal Membranes by FT-IR Spectroscopy

Computationally Assessing the Bioactivation of Drugs by N‑Dealkylation

Identification of Optimal Urinary Biomarkers of Synthetic Cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID, and BZO-CHMOXIZID for Illicit Abuse Monitoring

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