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Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest Old

Neurology, 2022-09, Vol.99 (10), p.e1067

2022

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TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43

Neurobiology of disease, 2024-04, Vol.193, p.106437-106437, Article 106437

2024

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Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy

Movement disorders, 2017-02, Vol.32 (2), p.246-255

2017

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Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

Nature communications, 2023-10, Vol.14 (1), p.6492-6492, Article 6492

2023

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Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy

RNA biology, 2021-11, Vol.18 (11), p.1546-1554

2021

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Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Acta neuropathologica, 2024-06, Vol.147 (1), p.93, Article 93

2024

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Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Nature communications, 2014-09, Vol.5 (1), p.4824, Article 4824

2014

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Symptomatic Profile and Cognitive Performance in Autopsy-Confirmed Limbic-Predominant Age-Related TDP-43 Encephalopathy With Comorbid Alzheimer Disease

Journal of neuropathology and experimental neurology, 2022-12, Vol.81 (12), p.975-987

2022

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Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons

Neurology, 2020-01, Vol.94 (2), p.e142

2020

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Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old

Journal of Alzheimer's disease, 2021-01, Vol.79 (1), p.389

2021

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Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

Human molecular genetics, 2013-10, Vol.22 (R1), p.R77-R87

2013

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TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression

Nature communications, 2024-05, Vol.15 (1), p.4163-4163, Article 4163

2024

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Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker

The Journal of neuroscience, 2014-09, Vol.34 (37), p.12368-12378

2014

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TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

Annals of neurology, 2015-11, Vol.78 (5), p.697-709

2015

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Limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change and microvascular pathologies in community‐dwelling older persons

Brain pathology (Zurich, Switzerland), 2021-05, Vol.31 (3), p.e12939-n/a

2021

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Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A

Acta neuropathologica, 2015-01, Vol.129 (1), p.53-64

2015

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Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis

Journal of neurology, neurosurgery and psychiatry, 2017-11, Vol.88 (11), p.908

2017

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Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies

Cerebral cortex (New York, N.Y. 1991), 2017-07, Vol.27 (7), p.3630-3647

2017

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Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy

The Journal of neuroscience, 2016-07, Vol.36 (29), p.7707-7717

2016

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Parkinson's disease and parkinsonism: neuropathology

Cold Spring Harbor perspectives in medicine, 2012-08, Vol.2 (8), p.a009258-a009258

Dickson, Dennis W

2012

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TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes

Brain (London, England : 1878), 2015-10, Vol.138 (Pt 10), p.3110-3122

2015

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Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis

Neurology, 2022-04, Vol.98 (14), p.e1422

2022

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Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

Brain (London, England : 1878), 2023-07, Vol.146 (7), p.2975-2988

2023

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Prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults: systematic review and meta‐analysis

Neuropathology and applied neurobiology, 2018-04, Vol.44 (3), p.286-297

2018

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Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

Neurobiology of disease, 2021-05, Vol.152, p.105289-105289, Article 105289

2021

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Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest Old

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43

Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins

Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

Symptomatic Profile and Cognitive Performance in Autopsy-Confirmed Limbic-Predominant Age-Related TDP-43 Encephalopathy With Comorbid Alzheimer Disease

Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons

Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old

Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders

TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

Limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change and microvascular pathologies in community‐dwelling older persons

Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A

Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis

Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy

Parkinson's disease and parkinsonism: neuropathology

TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes

Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies

Prevalence of transactive response DNA‐binding protein 43 (TDP‐43) proteinopathy in cognitively normal older adults: systematic review and meta‐analysis

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

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