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Benznidazole self-emulsifying delivery system: A novel alternative dosage form for Chagas disease treatment

European journal of pharmaceutical sciences, 2020-03, Vol.145, p.105234-105234, Article 105234

2020

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Chagas disease

The Lancet (British edition), 2010-04, Vol.375 (9723), p.1388-1402

2010

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Transbuccal delivery of benznidazole associated with monoterpenes: permeation studies and mechanistic insights

European journal of pharmaceutical sciences, 2020-02, Vol.143, p.105177-105177, Article 105177

2020

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American Trypanosomiasis (Chagas Disease)

Infectious disease clinics of North America, 2012-06, Vol.26 (2), p.275-291

2012

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Biological characteristics of the Trypanosoma cruzi Arequipa strain make it a good model for Chagas disease drug discovery

Acta tropica, 2022-12, Vol.236, p.106679-106679, Article 106679

2022

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A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

Science translational medicine, 2020-10, Vol.12 (567)

2020

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Interaction between peripheral blood mononuclear cells and Trypanosoma cruzi -infected adipocytes: implications for treatment failure and induction of immunomodulatory mechanisms in adipose tissue

Frontiers in immunology, 2024-03, Vol.15, p.1280877-1280877

2024

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Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: a prospective cohort study in two Spanish referral centres

Clinical microbiology and infection, 2020-03, Vol.26 (3), p.384.e1-384.e4

2020

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Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

International journal of pharmaceutics, 2021-03, Vol.596, p.120240-120240, Article 120240

2021

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Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

International journal of pharmaceutics, 2023-07, Vol.642, p.123120-123120, Article 123120

2023

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Exploring molecular docking with E-pharmacophore and QSAR models to predict potent inhibitors of 14-α-demethylase protease from Moringa spp

Pharmacological research. Modern Chinese medicine, 2022-09, Vol.4, p.100147, Article 100147

Omoboyowa, Damilola Alex

2022

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Unveiling challenges in real-time PCR strategies for detecting treatment failure: observations from clinical trials on chronic Chagas disease

Frontiers in parasitology, 2023-09, Vol.2

Schijman, Alejandro G.

2023

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Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon

Experimental parasitology, 2021-09, Vol.228, p.108136-108136, Article 108136

2021

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Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

Memórias do Instituto Oswaldo Cruz, 2017-03, Vol.112 (3), p.224-235

2017

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Trypanocidal Activity and Increased Solubility of Benznidazole Incorporated in PEG 4000 and Its Derivatives

Journal of the Brazilian Chemical Society, 2021-06, Vol.32 (6), p.1162-1172

2021

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Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial

The Lancet infectious diseases, 2024-04, Vol.24 (4), p.386-394

2024

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The antitripanocide Benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

Toxicology and applied pharmacology, 2016-08, Vol.304, p.90-98

2016

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Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs

Experimental parasitology, 2022-07, Vol.238, p.108266-108266, Article 108266

2022

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Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole

International journal of pharmaceutics, 2022-03, Vol.616, p.121487-121487, Article 121487

2022

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Preclinical evaluation of combined therapy with amiodarone and low-dose benznidazole in a mouse model of chronic Trypanosoma cruzi infection

Biomedicine & pharmacotherapy, 2024-06, Vol.175, p.116742, Article 116742

2024

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Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients

Antimicrobial agents and chemotherapy, 2021-02, Vol.65 (3)

2021

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The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Organic & biomolecular chemistry, 2019-07, Vol.17 (28), p.679-6798

2019

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Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions

International journal of pharmaceutics, 2019-01, Vol.555, p.36-48

2019

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Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes

European journal of pharmaceutical sciences, 2018-07, Vol.120, p.107-122

2018

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Benznidazole for the treatment of Chagas disease

Expert review of anti-infective therapy, 2021-05, Vol.19 (5), p.547-556

2021

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Benznidazole self-emulsifying delivery system: A novel alternative dosage form for Chagas disease treatment

Chagas disease

Transbuccal delivery of benznidazole associated with monoterpenes: permeation studies and mechanistic insights

American Trypanosomiasis (Chagas Disease)

Biological characteristics of the Trypanosoma cruzi Arequipa strain make it a good model for Chagas disease drug discovery

A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease

Interaction between peripheral blood mononuclear cells and Trypanosoma cruzi -infected adipocytes: implications for treatment failure and induction of immunomodulatory mechanisms in adipose tissue

Comparison of the toxicity of two treatment schemes with benznidazole for chronic Chagas disease: a prospective cohort study in two Spanish referral centres

Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

Exploring molecular docking with E-pharmacophore and QSAR models to predict potent inhibitors of 14-α-demethylase protease from Moringa spp

Unveiling challenges in real-time PCR strategies for detecting treatment failure: observations from clinical trials on chronic Chagas disease

Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

Trypanocidal Activity and Increased Solubility of Benznidazole Incorporated in PEG 4000 and Its Derivatives

Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial

The antitripanocide Benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs

Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole

Preclinical evaluation of combined therapy with amiodarone and low-dose benznidazole in a mouse model of chronic Trypanosoma cruzi infection

Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Tailoring microstructural, drug release properties, and antichagasic efficacy of biocompatible oil-in-water benznidazol-loaded nanoemulsions

Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes

Benznidazole for the treatment of Chagas disease

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