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Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system

Antimicrobial agents and chemotherapy, 2024-10, Vol.68 (10), p.e0069424

2024

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Molecular mechanisms of multiple toxin–antitoxin systems are coordinated to govern the persister phenotype

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (27), p.10891-10891

2013

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Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins

Journal of molecular biology, 2015-03, Vol.427 (6), p.1224-1238

2015

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Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

Nucleic acids research, 2015-09, Vol.43 (15), p.7624-7637

2015

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Small Toxic Proteins and the Antisense RNAs That Repress Them

Microbiology and Molecular Biology Reviews, 2008-12, Vol.72 (4), p.579-589

2008

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Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils

PloS one, 2014-01, Vol.9 (1), p.e84992

2014

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Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

PLoS biology, 2019-06, Vol.17 (6), p.e3000311-e3000311

2019

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Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)

Vaccine, 2010-01, Vol.28 (4), p.965-969

2010

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Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (8), p.3360-3365

2011

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Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages

Journal of leukocyte biology, 2020-09, Vol.108 (3), p.967-981

2020

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Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa

Microbial pathogenesis, 2014-09, Vol.74, p.25-32

2014

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Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC

Journal of medicinal chemistry, 2020-11, Vol.63 (22), p.13669-13679

2020

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The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin

Toxins, 2015-10, Vol.7 (11), p.4455-4467

2015

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Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds

PloS one, 2016-11, Vol.11 (11), p.e0166477

2016

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In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.892-900

2014

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Targeting of Alpha-Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

The Journal of infectious diseases, 2010-10, Vol.202 (7), p.1050-1058

2010

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Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

Journal of molecular biology, 2013-05, Vol.425 (10), p.1641-1654

2013

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Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.591-602

2011

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Targeting Staphylococcus aureus α-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections

The Journal of infectious diseases, 2014-10, Vol.210 (7), p.1012-1018

2014

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Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin

The Journal of infectious diseases, 2012-07, Vol.206 (2), p.292-301

2012

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The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile

International journal of molecular sciences, 2021-03, Vol.22 (6), p.2926

2021

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18β-Glycyrrhetinic Acid Inhibits Methicillin-Resistant Staphylococcus aureus Survival and Attenuates Virulence Gene Expression

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.241-247

2013

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Field evolved resistance in Helicoverpa armigera (Lepidoptera: Noctuidae) to Bacillus thuringiensis toxin Cry1Ac in Pakistan

PloS one, 2012-10, Vol.7 (10), p.e47309

2012

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Autocatalytic cleavage of Clostridium difficile toxin B

Nature, 2007-03, Vol.446 (7134), p.415-419

2007

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Limiting damage during infection: lessons from infection tolerance for novel therapeutics

PLoS biology, 2014-01, Vol.12 (1), p.e1001769

2014

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Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal Pseudomonas aeruginosa infection via inhibition of toxin translocation by the type III secretion system

Molecular mechanisms of multiple toxin–antitoxin systems are coordinated to govern the persister phenotype

Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins

Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

Small Toxic Proteins and the Antisense RNAs That Repress Them

Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)

Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci

Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages

Aspirin is an efficient inhibitor of quorum sensing, virulence and toxins in Pseudomonas aeruginosa

Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC

The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin

Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds

In Vitro and In Vivo Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

Targeting of Alpha-Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus α-Hemolysin

Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

Targeting Staphylococcus aureus α-Toxin as a Novel Approach to Reduce Severity of Recurrent Skin and Soft-Tissue Infections

Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of α-Hemolysin

The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile

18β-Glycyrrhetinic Acid Inhibits Methicillin-Resistant Staphylococcus aureus Survival and Attenuates Virulence Gene Expression

Field evolved resistance in Helicoverpa armigera (Lepidoptera: Noctuidae) to Bacillus thuringiensis toxin Cry1Ac in Pakistan

Autocatalytic cleavage of Clostridium difficile toxin B

Limiting damage during infection: lessons from infection tolerance for novel therapeutics

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