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Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia

Journal of the American Society of Nephrology, 2019-04, Vol.30 (4), p.578-593

2019

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Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis

American journal of physiology. Renal physiology, 2017-05, Vol.312 (5), p.F819-F835

2017

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Extracellular Nucleotides and P2 Receptors in Renal Function

Physiological reviews, 2020-01, Vol.100 (1), p.211-269

2020

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SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice

American journal of physiology. Renal physiology, 2014-01, Vol.306 (2), p.F194-F204

2014

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Adenosine and Kidney Function

Physiological reviews, 2006-07, Vol.86 (3), p.901-940

2006

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SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1

American journal of physiology. Renal physiology, 2019-01, Vol.316 (1), p.F173-F185

2019

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Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1

American Journal of Physiology - Renal Physiology, 2009-09, Vol.297 (3), p.F704-F712

2009

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Development of SGLT1 and SGLT2 inhibitors

Diabetologia, 2018-10, Vol.61 (10), p.2079-2086

2018

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Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia

American journal of physiology. Renal physiology, 2014-01, Vol.306 (2), p.F188-F193

2014

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Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

American journal of physiology. Regulatory, integrative and comparative physiology, 2012-01, Vol.302 (1), p.R75-R83

2012

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How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?

Nephrology, dialysis, transplantation, 2024-09, Vol.39 (10), p.1565-1573

Vallon, Volker

2024

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Functional significance of channels and transporters expressed in the inner ear and kidney

American Journal of Physiology: Cell Physiology, 2007-10, Vol.293 (4), p.C1187-C1208

2007

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Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Diabetes (New York, N.Y.), 2012-01, Vol.61 (1), p.187-196

2012

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State-of-the-Art-Review: Mechanisms of Action of SGLT2 Inhibitors and Clinical Implications

American journal of hypertension, 2024-10, Vol.37 (11), p.841-852

Vallon, Volker

2024

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Effect of renal tubule-specific knockdown of the Na + /H + exchanger NHE3 in Akita diabetic mice

American journal of physiology. Renal physiology, 2019-08, Vol.317 (2), p.F419-F434

2019

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Tubuloglomerular feedback and the control of glomerular filtration rate

News in physiological sciences, 2003-08, Vol.18 (4), p.169-174

Vallon, Volker

2003

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(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms

Physiological reviews, 2006-10, Vol.86 (4), p.1151-1178

2006

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A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans

Naunyn-Schmiedeberg's archives of pharmacology, 2015-08, Vol.388 (8), p.801-816

2015

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Knockout of Na + -glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration

American journal of physiology. Renal physiology, 2019-07, Vol.317 (1), p.F207-F217

2019

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Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Physiological reports, 2020-01, Vol.8 (2), p.e14360-n/a

2020

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The physiological impact of the serum and glucocorticoid-inducible kinase SGK1

Current opinion in nephrology and hypertension, 2009-09, Vol.18 (5), p.439-448

2009

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Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat

American journal of physiology. Renal physiology, 2018-09, Vol.315 (3), p.F653-F664

2018

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Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Scientific reports, 2016-05, Vol.6 (1), p.26428-26428, Article 26428

2016

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Mineralocorticoid-Induced Sodium Appetite and Renal Salt Retention: Evidence for Common Signaling and Effector Mechanisms

Nephron, 2014-01, Vol.128 (1-2), p.8-16

2014

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Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences

American Journal of Physiology: Cell Physiology, 2012-04, Vol.302 (8), p.C1174-C1188

2012

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Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia

Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis

Extracellular Nucleotides and P2 Receptors in Renal Function

SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice

Adenosine and Kidney Function

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1

Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1

Development of SGLT1 and SGLT2 inhibitors

Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia

Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?

Functional significance of channels and transporters expressed in the inner ear and kidney

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

State-of-the-Art-Review: Mechanisms of Action of SGLT2 Inhibitors and Clinical Implications

Effect of renal tubule-specific knockdown of the Na + /H + exchanger NHE3 in Akita diabetic mice

Tubuloglomerular feedback and the control of glomerular filtration rate

(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms

A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans

Knockout of Na + -glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration

Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

The physiological impact of the serum and glucocorticoid-inducible kinase SGK1

Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Mineralocorticoid-Induced Sodium Appetite and Renal Salt Retention: Evidence for Common Signaling and Effector Mechanisms

Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences

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