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Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

Cancer medicine (Malden, MA), 2017-04, Vol.6 (4), p.798-808

2017

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novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Transgenic research, 2014-06, Vol.23 (3), p.441-453

2014

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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Nature biotechnology, 2000-10, Vol.18 (10), p.1086-1090

2000

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Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector

Biochemical and biophysical research communications, 2008-05, Vol.369 (3), p.807-811

2008

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Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation

Nucleic acids research, 2024-02, Vol.52 (3), p.1498-1511

2024

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Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

The Journal of clinical investigation, 2004-02, Vol.113 (4), p.561-568

2004

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Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates

ACS chemical biology, 2022-02, Vol.17 (2), p.292-298

2022

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The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

Scientific reports, 2016-01, Vol.6 (1), p.18849-18849, Article 18849

2016

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S2B1-1 Nobel approaches to facilitate the genome-based discovery of drug targets and the development of human antiboby therapeutics

Journal of Pharmacological Sciences, 2008, Vol.106 (suppl.1), p.27-27

Kazuma Tomizuka

2008

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R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation

Blood advances, 2024-02, Vol.8 (3), p.725-731

2024

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Osteoblast Stimulating Factor-5 Regulates B Lymphopoiesis Via Inhibiting Pre B Cell Proliferation

Blood, 2014-12, Vol.124 (21), p.2926-2926

2014

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Targeted deletion of the tybe IIb Na+-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality

Biochemical and biophysical research communications, 2009-04, Vol.381 (4), p.482-486

2009

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Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice

Journal of human genetics, 2001-10, Vol.46 (10), p.600-603

2001

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Estrogen‐inducible sFRP5 inhibits early B‐lymphopoiesis in vivo, but not during pregnancy

European journal of immunology, 2015-05, Vol.45 (5), p.1390-1401

2015

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Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle

Nature genetics, 2004-07, Vol.36 (7), p.775-780

2004

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Strategy for technology development of antibody therapeutics

Folia Pharmacologica Japonica, 2016, Vol.147(4), pp.235-240

2016

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A new model mouse for Duchenne muscular dystrophy produced by 2.4 Mb deletion of dystrophin gene using Cre- loxP recombination system

Biochemical and biophysical research communications, 2005-03, Vol.328 (2), p.507-516

2005

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Production of a Diverse Repertoire of Human Antibodies in Genetically Engineered Mice

MICROBIOLOGY and IMMUNOLOGY, 1998, Vol.42(3), pp.143-150

1998

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SFRP5 Inhibits Early Stages Of B-Cell Differentiation and Modulates Estrogen-Related Changes In The Immune System

Blood, 2013-11, Vol.122 (21), p.2422-2422

2013

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Diversity of theHO gene encoding an endonuclease for mating-type conversion in the bottom fermenting yeastSaccharomyces pastorianus

Yeast (Chichester, England), 2000-10, Vol.16 (14), p.1335-1343

2000

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Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

Nature genetics, 1997-06, Vol.16 (2), p.133-143

1997

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Protection of the Intestinal Epithelium from Conditioning with R-spondin1 Ameliorates Graft-Versus-Host Disease

Blood, 2008-11, Vol.112 (11), p.66-66

2008

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Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome

Human molecular genetics, 2001-05, Vol.10 (11), p.1163-1175

2001

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Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice

Nature genetics, 1997-06, Vol.16 (2), p.133-143

1997

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抗体医薬の技術戦略

日本薬理学雑誌, 2016, Vol.147(4), pp.235-240

2016

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Novel anticarcinoembryonic antigen antibody–drug conjugate has antitumor activity in the existence of soluble antigen

novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector

Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates

The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders

S2B1-1 Nobel approaches to facilitate the genome-based discovery of drug targets and the development of human antiboby therapeutics

R-Spondin1 protects gastric stem cells and mitigates gastric GVHD in allogeneic hematopoietic stem cell transplantation

Osteoblast Stimulating Factor-5 Regulates B Lymphopoiesis Via Inhibiting Pre B Cell Proliferation

Targeted deletion of the tybe IIb Na+-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality

Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice

Estrogen‐inducible sFRP5 inhibits early B‐lymphopoiesis in vivo, but not during pregnancy

Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle

Strategy for technology development of antibody therapeutics

A new model mouse for Duchenne muscular dystrophy produced by 2.4 Mb deletion of dystrophin gene using Cre- loxP recombination system

Production of a Diverse Repertoire of Human Antibodies in Genetically Engineered Mice

SFRP5 Inhibits Early Stages Of B-Cell Differentiation and Modulates Estrogen-Related Changes In The Immune System

Diversity of theHO gene encoding an endonuclease for mating-type conversion in the bottom fermenting yeastSaccharomyces pastorianus

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

Protection of the Intestinal Epithelium from Conditioning with R-spondin1 Ameliorates Graft-Versus-Host Disease

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome

Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice

抗体医薬の技術戦略

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