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Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Acta pharmaceutica Sinica. B, 2023-07, Vol.13 (7), p.3080-3092

2023

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Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

European journal of medicinal chemistry, 2014-07, Vol.82, p.490-497

2014

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Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5268-5277

2017

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Chlorin p6‑Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy

Journal of medicinal chemistry, 2016-05, Vol.59 (10), p.4999-5010

2016

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Discovery of a new chemical scaffold for the treatment of superbug Candida auris infections

Emerging microbes & infections, 2023-12, Vol.12 (1), p.2208687-2208687

2023

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A novel route for the synthesis of androgen receptor antagonist enzalutamide

Chinese chemical letters, 2023-06, Vol.34 (6), p.108096-453, Article 108096

2023

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Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors

European journal of medicinal chemistry, 2018-01, Vol.143, p.1510-1523

2018

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Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.10606-10620

2021

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Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

Acta pharmaceutica Sinica. B, 2022-01, Vol.12 (1), p.274-290

2022

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Targeting Protein-Protein Interactions by Small Molecules

1st ed. 2018 edition., 2018

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Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

Antimicrobial Agents and Chemotherapy, 2009-08, Vol.53 (8), p.3487-3495

2009

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A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment

Acta pharmaceutica Sinica. B, 2024-05, Vol.14 (5), p.2228-2246

2024

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Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

European journal of medicinal chemistry, 2011-11, Vol.46 (11), p.5276-5282

2011

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Chalcone: A Privileged Structure in Medicinal Chemistry

Chemical reviews, 2017-06, Vol.117 (12), p.7762-7810

2017

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Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping

European journal of medicinal chemistry, 2011-05, Vol.46 (5), p.1706-1712

2011

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Scaffold hopping of sampangine: Discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4090-4094

2014

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Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors

International journal of molecular sciences, 2014-09, Vol.15 (9), p.15741-15753

2014

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Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

European journal of medicinal chemistry, 2012-04, Vol.50, p.196-208

2012

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Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking

Journal of medicinal chemistry, 2006-04, Vol.49 (8), p.2512-2525

2006

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Fragment Informatics and Computational Fragment-Based Drug Design: An Overview and Update

Medicinal research reviews, 2013-05, Vol.33 (3), p.554-598

2013

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Emerging New Targets for the Treatment of Resistant Fungal Infections

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5484-5511

2018

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Strategies for designing proteolysis targeting chimaeras (PROTACs)

Medicinal research reviews, 2022-05, Vol.42 (3), p.1280-1342

2022

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Structure–activity relationship and antitumor activity of thio-benzodiazepines as p53–MDM2 protein–protein interaction inhibitors

European journal of medicinal chemistry, 2012-10, Vol.56, p.10-16

2012

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Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

Angewandte Chemie (International ed.), 2012-03, Vol.51 (10), p.2282-2284

International ed. in English, 2012

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Tackling Fungal Resistance by Biofilm Inhibitors

Journal of medicinal chemistry, 2017-03, Vol.60 (6), p.2193-2211

2017

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Controlling antifungal activity with light: Optical regulation of fungal ergosterol biosynthetic pathway with photo-responsive CYP51 inhibitors

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

Chlorin p6‑Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy

Discovery of a new chemical scaffold for the treatment of superbug Candida auris infections

A novel route for the synthesis of androgen receptor antagonist enzalutamide

Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

Targeting Protein-Protein Interactions by Small Molecules

Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

Chalcone: A Privileged Structure in Medicinal Chemistry

Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping

Scaffold hopping of sampangine: Discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans

Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors

Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking

Fragment Informatics and Computational Fragment-Based Drug Design: An Overview and Update

Emerging New Targets for the Treatment of Resistant Fungal Infections

Strategies for designing proteolysis targeting chimaeras (PROTACs)

Structure–activity relationship and antitumor activity of thio-benzodiazepines as p53–MDM2 protein–protein interaction inhibitors

Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

Tackling Fungal Resistance by Biofilm Inhibitors

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