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Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay

Journal of neuroscience methods, 2000-10, Vol.102 (1), p.61-68

2000

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Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Neuropharmacology, 2005-06, Vol.48 (7), p.1002-1011

2005

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A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.373-378

2005

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Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Journal of lipid research, 2004-12, Vol.45 (12), p.2368-2376

2004

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gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13077-13085

2003

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Modulation of ion channel activity: a key function of the protein kinase C enzyme family

Pharmacological reviews, 1989-06, Vol.41 (2), p.211

1989

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Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung

Cellular and molecular biology (Noisy-le-Grand, France), 1998-11, Vol.44 (7), p.1147

1998

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Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Journal of neurochemistry, 2004-09, Vol.90 (6), p.1312-1320

2004

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Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (1), p.37-41

2003

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Gamma-secretase inhibition

Biochemical Society transactions, 2002-08, Vol.30 (4), p.534

2002

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Peripheral Arterial Disease and Bypass Surgery in the Diabetic Lower Limb

The Medical clinics of North America, 2013-09, Vol.97 (5), p.821-834

2013

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Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

Neurobiology of aging, 2004-10, Vol.25 (9), p.1175-1185

2004

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The C‐terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome‐dependent mechanism distinct from γ‐secretase

European journal of biochemistry, 2001-10, Vol.268 (20), p.5329-5336

2001

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γ-Secretase: characterization and implication for Alzheimer disease therapy

Neurobiology of aging, 2002-11, Vol.23 (6), p.1023-1030

2002

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Distinct cellular expression of beta I- and beta II-subspecies of protein kinase C in rat cerebellum

The Journal of neuroscience, 1988-10, Vol.8 (10), p.3850-3856

1988

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Cerebrospinal fluid levels of β-amyloid(42) in patients with Alzheimerʼs disease are related to the exon 2 polymorphism of the cathepsin D gene

Neuroreport, 2002-07, Vol.13 (10), p.1291-1294

2002

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Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of β-amyloid in rat PC12 cells

Neuroscience letters, 1995-01, Vol.184 (2), p.113-116

1995

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Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Neurobiology of disease, 2001-08, Vol.8 (4), p.717-722

2001

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Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion

Neuroscience letters, 1995-09, Vol.197 (3), p.211-214

1995

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Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

FEBS letters, 1989-01, Vol.243 (2), p.177-182

1989

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Peripheral Arterial Disease

Endocrinology and metabolism clinics of North America, 2014-03, Vol.43 (1), p.149-166

2014

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Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids

Molecular endocrinology (Baltimore, Md.), 1988-11, Vol.2 (11), p.1043-1048

1988

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Cellular MTT reduction distinguishes the mechanism of action of β-amyloid from that of tachykinin receptor peptides

Neuropeptides (Edinburgh), 1996-04, Vol.30 (2), p.125-132

Shearman, M.S

1996

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Synaptosomal Protein Kinase C Subspecies: B. Down‐Regulation Promoted by Phorbol Ester and Its Effect on Evoked Norepinephrine Release

Journal of neurochemistry, 1991-04, Vol.56 (4), p.1263-1269

1991

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Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro

Neuroreport, 1998-09, Vol.9 (13), p.3053-3058

1998

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Quantitation of amyloid-β peptides in biological milieu using a novel homogeneous time-resolved fluorescence (HTRF) assay

Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta

Modulation of ion channel activity: a key function of the protein kinase C enzyme family

Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung

Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Synthesis and γ-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres

Gamma-secretase inhibition

Peripheral Arterial Disease and Bypass Surgery in the Diabetic Lower Limb

Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD

The C‐terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome‐dependent mechanism distinct from γ‐secretase

γ-Secretase: characterization and implication for Alzheimer disease therapy

Distinct cellular expression of beta I- and beta II-subspecies of protein kinase C in rat cerebellum

Cerebrospinal fluid levels of β-amyloid(42) in patients with Alzheimerʼs disease are related to the exon 2 polymorphism of the cathepsin D gene

Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of β-amyloid in rat PC12 cells

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion

Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

Peripheral Arterial Disease

Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids

Cellular MTT reduction distinguishes the mechanism of action of β-amyloid from that of tachykinin receptor peptides

Synaptosomal Protein Kinase C Subspecies: B. Down‐Regulation Promoted by Phorbol Ester and Its Effect on Evoked Norepinephrine Release

Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro

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