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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

Malaria journal, 2021-02, Vol.20 (1), p.107-15, Article 107

2021

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An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth

Cancer research (Chicago, Ill.), 2007-01, Vol.67 (2), p.573-579

2007

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Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

PloS one, 2016-10, Vol.11 (10), p.e0164100

2016

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Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Nature communications, 2023-03, Vol.14 (1), p.1297-1, Article 1297

2023

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Inhibition of a viral enzyme by a small-molecule dimer disruptor

Nature chemical biology, 2009-09, Vol.5 (9), p.640-646

2009

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Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (29), p.11878-11883

2011

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Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

Bioscience reports, 2018-08, Vol.38 (4)

2018

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An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma

Cancer cell, 2011-09, Vol.20 (3), p.384-399

2011

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Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

Journal of organic chemistry, 2014-08, Vol.79 (15), p.6913-6938

2014

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Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

PloS one, 2015-10, Vol.10 (10), p.e0137867-e0137867

2015

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Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

Malaria journal, 2022-02, Vol.21 (1), p.49-49, Article 49

2022

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Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Science signaling, 2018-08, Vol.11 (543)

2018

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Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.15-21

2011

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Reporting data from high-throughput screening of small-molecule libraries

Nature chemical biology, 2007-08, Vol.3 (8), p.438-441

2007

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Non-competitive androgen receptor inhibition in vitro and in vivo

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (17), p.7233-7238

2009

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Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

PloS one, 2015-04, Vol.10 (4), p.e0123598

2015

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Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4535-4543

2006

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Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.163-173

2012

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Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4640-4651

2012

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Searching for New Antimalarial Therapeutics amongst Known Drugs

Chemical biology & drug design, 2006-06, Vol.67 (6), p.409-416

2006

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Antimalarials in Development in 2014

Chemical reviews, 2014-11, Vol.114 (22), p.11221-11241

2014

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Antimalarial activity of thiosemicarbazones and purine derived nitriles

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3546-3549

2009

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Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen

Antimicrobial agents and chemotherapy, 2015-03, Vol.59 (3), p.1389-1397

2015

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8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

PloS one, 2015-05, Vol.10 (5), p.e0124423-e0124423

2015

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Quantification of the Vitamin D Receptor−Coregulator Interaction

Biochemistry (Easton), 2009-02, Vol.48 (7), p.1454-1461

2009

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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones

An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth

Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Inhibition of a viral enzyme by a small-molecule dimer disruptor

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain

An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Whole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration

Reporting data from high-throughput screening of small-molecule libraries

Non-competitive androgen receptor inhibition in vitro and in vivo

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum

Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria

Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators

Searching for New Antimalarial Therapeutics amongst Known Drugs

Antimalarials in Development in 2014

Antimalarial activity of thiosemicarbazones and purine derived nitriles

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

Quantification of the Vitamin D Receptor−Coregulator Interaction

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