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Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody

PloS one, 2015, Vol.10 (1), p.e0116577-e0116577

2015

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Inhibitors—Recent insights

Haemophilia : the official journal of the World Federation of Hemophilia, 2021-02, Vol.27 (S3), p.28-36

2021

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Progress toward inducing immunologic tolerance to factor VIII

Blood, 2013-05, Vol.121 (22), p.4449-4456

2013

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Lack of factor VIII detection in humans and dogs with an intron 22 inversion challenges hypothesis regarding inhibitor risk

Journal of thrombosis and haemostasis, 2024-09

2024

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Hemophilia A Inhibitor Treatment: The Promise of Engineered T Cell Therapy

Translational research : the journal of laboratory and clinical medicine, 2017-09, Vol.187, p.44-52

2017

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Inhibitory antibodies in hemophilia A

Current opinion in hematology, 2012-09, Vol.19 (5), p.399-405

Pratt, Kathleen P

2012

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Presenting ADAMTS13 on a TTP-associated MHC

Blood, 2013-04, Vol.121 (17), p.3302-3303

Pratt, Kathleen P.

2013

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A unique major histocompatibility complex Class II–binding register correlates with HLA‐DR11–associated immunogenicity of the major K blood group antigen

Transfusion (Philadelphia, Pa.), 2018-05, Vol.58 (5), p.1171-1181

2018

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Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding site

Thrombosis and haemostasis, 2004-09, Vol.92 (3), p.522-528

2004

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Seraph 100 Microbind Affinity Blood Filter Does Not Clear Antibiotics: An Analysis of Antibiotic Concentration Data from PURIFY-OBS

Blood purification, 2024-01, Vol.53 (5), p.379-385

2024

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T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Blood, 2016-10, Vol.128 (16), p.2043-2054

2016

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Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Blood, 2015-08, Vol.126 (7), p.895-904

2015

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Anti-FVIII antibodies in Black and White hemophilia A subjects: do F8 haplotypes play a role?

Blood advances, 2023-09, Vol.7 (17), p.4983-4998

2023

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Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Nature medicine, 2013-10, Vol.19 (10), p.1318-1324

2013

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Avidity of human T cell receptor engineered CD4+ T cells drives T-helper differentiation fate

Cellular immunology, 2016-01, Vol.299, p.30-41

2016

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Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

Blood, 2009-08, Vol.114 (7), p.1423-1428

2009

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Covalent Inactivation of Factor VIII Antibodies from Hemophilia A Patients by an Electrophilic FVIII Analog

The Journal of biological chemistry, 2008-05, Vol.283 (18), p.11876-11886

2008

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Rare Factor VIII-reactive CD4 T cells in non-hemophilic blood characterized by ex vivo expansion and ELISPOTs with added costimulation

The Journal of immunology (1950), 2023-05, Vol.210 (1_Supplement), p.64-64.12

2023

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Higher Incidence of Neutralizing Anti-FVIII Antibodies (Inhibitors) in Black and Hispanic American Hemophilia A Patients Enrolled in the My Life, Our Future Programme

Blood, 2019-11, Vol.134 (Supplement_1), p.901-901

Pratt, Kathleen P.

2019

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B-Cell and T-Cell Epitopes in Anti-factor VIII Immune Responses

Clinical reviews in allergy & immunology, 2009-10, Vol.37 (2), p.80-95

2009

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Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

Blood, 2001-07, Vol.98 (1), p.13-19

2001

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SARS-CoV-2 Infection Risk Among Active Duty Military Members Deployed to a Field Hospital - New York City, April 2020

MMWR. Morbidity and mortality weekly report, 2021-03, Vol.70 (9), p.308-311

2021

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Crystal structure of a 30 kDa C-terminal fragment from the γ chain of human fibrinogen

Structure (London), 1997-01, Vol.5 (1), p.125-138

1997

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New insights into binding interfaces of coagulation factors V and VIII and their homologues lessons from high resolution crystal structures

Current protein & peptide science, 2002-06, Vol.3 (3), p.313-339

2002

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Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4+ T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Blood, 2019-11, Vol.134 (Supplement_1), p.2413-2413

2019

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Six amino acid residues in a 1200 Å2 interface mediate binding of factor VIII to an IgG4κ inhibitory antibody

Inhibitors—Recent insights

Progress toward inducing immunologic tolerance to factor VIII

Lack of factor VIII detection in humans and dogs with an intron 22 inversion challenges hypothesis regarding inhibitor risk

Hemophilia A Inhibitor Treatment: The Promise of Engineered T Cell Therapy

Inhibitory antibodies in hemophilia A

Presenting ADAMTS13 on a TTP-associated MHC

A unique major histocompatibility complex Class II–binding register correlates with HLA‐DR11–associated immunogenicity of the major K blood group antigen

Immunodominant T-cell epitopes in the factor VIII C2 domain are located within an inhibitory antibody binding site

Seraph 100 Microbind Affinity Blood Filter Does Not Clear Antibiotics: An Analysis of Antibiotic Concentration Data from PURIFY-OBS

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Anti-FVIII antibodies in Black and White hemophilia A subjects: do F8 haplotypes play a role?

Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Avidity of human T cell receptor engineered CD4+ T cells drives T-helper differentiation fate

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

Covalent Inactivation of Factor VIII Antibodies from Hemophilia A Patients by an Electrophilic FVIII Analog

Rare Factor VIII-reactive CD4 T cells in non-hemophilic blood characterized by ex vivo expansion and ELISPOTs with added costimulation

Higher Incidence of Neutralizing Anti-FVIII Antibodies (Inhibitors) in Black and Hispanic American Hemophilia A Patients Enrolled in the My Life, Our Future Programme

B-Cell and T-Cell Epitopes in Anti-factor VIII Immune Responses

Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

SARS-CoV-2 Infection Risk Among Active Duty Military Members Deployed to a Field Hospital - New York City, April 2020

Crystal structure of a 30 kDa C-terminal fragment from the γ chain of human fibrinogen

New insights into binding interfaces of coagulation factors V and VIII and their homologues lessons from high resolution crystal structures

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4+ T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

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