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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6784-6802

2015

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4866-4871

2015

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Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx‑1

ACS chemical biology, 2019-01, Vol.14 (1), p.118-130

2019

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Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1111-1121

2019

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Discovery of Tarantula Venom-Derived Na V 1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9500-9512

2018

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Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx‑1 Peptide–Antibody Conjugates

ACS chemical biology, 2017-09, Vol.12 (9), p.2427-2435

2017

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Fmoc-Protein Synthesis: Preparation of Peptide Thioesters Using a Side-Chain Anchoring Strategy

International journal of peptide research and therapeutics, 2005-06, Vol.11 (2), p.117-123

2005

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Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2758-2765

2008

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Oxidative folding of hepcidin at acidic pH

Biopolymers, 2010, Vol.94 (2), p.257-264

2010

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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Biopolymers, 2013-07, Vol.100 (4), p.422-430

2013

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Engineering Antibody Reactivity for Efficient Derivatization to Generate Na V 1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates

ACS chemical biology, 2017-09, Vol.12 (9), p.2427-2435

2017

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Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS

Journal of the American Society for Mass Spectrometry, 2011-09, Vol.22 (9), p.1660-1667

2011

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Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor

Journal of medicinal chemistry, 2008-12, Vol.51 (24), p.7889-7897

2008

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Site-Specific Polymer Attachment to a CCL-5 (RANTES) Analogue by Oxime Exchange

Journal of the American Chemical Society, 2005-02, Vol.127 (5), p.1350-1351

2005

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A Chemical Approach to the Pharmaceutical Optimization of an Anti-HIV Protein

Journal of the American Chemical Society, 2007-10, Vol.129 (43), p.13153-13159

2007

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A New Approach to the Chemical Synthesis of Keto-Proteins

Journal of the American Chemical Society, 2003-11, Vol.125 (47), p.14238-14239

2003

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Synthesis of Difficult Cyclic Peptides by Inclusion of a Novel Photolabile Auxiliary in a Ring Contraction Strategy

Journal of the American Chemical Society, 1999-10, Vol.121 (42), p.9790-9796

1999

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An Activated O → N Acyl Transfer Auxiliary: Efficient Amide-Backbone Substitution of Hindered “Difficult” Peptides

Journal of organic chemistry, 2000-09, Vol.65 (18), p.5460-5468

2000

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Three-Dimensional Solution Structure of α-Conotoxin MII by NMR Spectroscopy: Effects of Solution Environment on Helicity

Biochemistry (Easton), 1998-11, Vol.37 (45), p.15621-15630

1998

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Unichemo Protection: A Concept for Chemical Synthesis This work was supported by the Danish National Research Foundation

Angewandte Chemie International Edition, 2001-10, Vol.40 (19), p.3655-3657

2001

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Graphical Abstract

Angewandte Chemie International Edition, 2001-10, Vol.40 (19), p.3489-3489

2001

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Solid-phase peptide synthesis using microwave irradiation

Methods in molecular biology (Clifton, N.J.), 2011, Vol.716, p.73

2011

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Cover Image, Volume 116, Number 9, September 2019

Biotechnology and bioengineering, 2019-09, Vol.116 (9), p.i-i

2019

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Challenges for protein chemical synthesis in the 21st century: Bridging genomics and proteomics

BIOPOLYM, 2000, Vol.55 (3), p.217-226

2000

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx‑1

Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

Discovery of Tarantula Venom-Derived Na V 1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx‑1 Peptide–Antibody Conjugates

Fmoc-Protein Synthesis: Preparation of Peptide Thioesters Using a Side-Chain Anchoring Strategy

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Engineering Na V 1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics

Oxidative folding of hepcidin at acidic pH

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Engineering Antibody Reactivity for Efficient Derivatization to Generate Na V 1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates

Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS

Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor

Site-Specific Polymer Attachment to a CCL-5 (RANTES) Analogue by Oxime Exchange

A Chemical Approach to the Pharmaceutical Optimization of an Anti-HIV Protein

A New Approach to the Chemical Synthesis of Keto-Proteins

Synthesis of Difficult Cyclic Peptides by Inclusion of a Novel Photolabile Auxiliary in a Ring Contraction Strategy

An Activated O → N Acyl Transfer Auxiliary: Efficient Amide-Backbone Substitution of Hindered “Difficult” Peptides

Three-Dimensional Solution Structure of α-Conotoxin MII by NMR Spectroscopy: Effects of Solution Environment on Helicity

Unichemo Protection: A Concept for Chemical Synthesis This work was supported by the Danish National Research Foundation

Graphical Abstract

Solid-phase peptide synthesis using microwave irradiation

Cover Image, Volume 116, Number 9, September 2019

Challenges for protein chemical synthesis in the 21st century: Bridging genomics and proteomics

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