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Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13480-13486

2003

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Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice

Food and chemical toxicology, 2020-02, Vol.136, p.110957, Article 110957

2020

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Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers

The Science of the total environment, 2023-08, Vol.888, p.164211-164211, Article 164211

2023

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Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis

Molecular and Cellular Biology, 2003-09, Vol.23 (17), p.6103-6116

2003

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Increased Resistance to Acetaminophen Hepatotoxicity in Mice Lacking Glutathione S-Transferase Pi

Proceedings of the National Academy of Sciences - PNAS, 2000-11, Vol.97 (23), p.12741-12745

2000

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Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

Communications biology, 2021-09, Vol.4 (1), p.1081-16, Article 1081

2021

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Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

Frontiers in pharmacology, 2017-11, Vol.8, p.881

2017

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A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Journal of proteome research, 2014-02, Vol.13 (2), p.866-874

2014

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Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice

Molecular neurobiology, 2013-04, Vol.47 (2), p.662-672

2013

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Effects of 2-MCPD on oxidative stress in different organs of male mice

Food and chemical toxicology, 2020-08, Vol.142, p.111459, Article 111459

2020

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In vivo stress reporters as early biomarkers of the cellular changes associated with progeria

Journal of cellular and molecular medicine, 2022-11, Vol.26 (21), p.5463-5472

2022

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Increased Skin Tumorigenesis in Mice Lacking Pi Class Glutathione S-Transferases

Proceedings of the National Academy of Sciences - PNAS, 1998-04, Vol.95 (9), p.5275-5280

1998

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Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H : Quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

Cancer research (Chicago, Ill.), 2005-04, Vol.65 (7), p.2644-2652

2005

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Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010-08, Vol.878 (23), p.2155-2162

2010

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Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Biochemical journal, 2005-06, Vol.388 (Pt 3), p.857-867

2005

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Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi

The Journal of biological chemistry, 2003-06, Vol.278 (25), p.22243-22249

2003

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Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1322

2008

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Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

PloS one, 2011-10, Vol.6 (10), p.e25707

2011

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Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

Molecular pharmacology, 2013-06, Vol.83 (6), p.1209

2013

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Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity

The Journal of pharmacology and experimental therapeutics, 2015-11, Vol.355 (2), p.137

2015

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Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Environmental pollution (1987), 2021-02, Vol.270, p.116053, Article 116053

2021

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Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Toxicological sciences, 2014-08, Vol.140 (2), p.259-270

2014

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Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites

The Journal of pharmacology and experimental therapeutics, 2017-10, Vol.363 (1), p.12

2017

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Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

The Journal of pharmacology and experimental therapeutics, 2007-07, Vol.322 (1), p.40

2007

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Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

Proceedings of the National Academy of Sciences - PNAS, 2024-02, Vol.121 (7), p.e2315069121-e2315069121

2024

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Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice

Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers

Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis

Increased Resistance to Acetaminophen Hepatotoxicity in Mice Lacking Glutathione S-Transferase Pi

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice

Effects of 2-MCPD on oxidative stress in different organs of male mice

In vivo stress reporters as early biomarkers of the cellular changes associated with progeria

Increased Skin Tumorigenesis in Mice Lacking Pi Class Glutathione S-Transferases

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H : Quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi

Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

Altered protein S-glutathionylation identifies a potential mechanism of resistance to acetaminophen-induced hepatotoxicity

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

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