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Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

ACS medicinal chemistry letters, 2011-04, Vol.2 (4), p.303-306

2011

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

The EMBO journal, 2003-08, Vol.22 (15), p.3803-3815

2003

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Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10312-10332

2021

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Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2022-07, Vol.130 (7), p.458-476

2022

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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

Microbiology (Society for General Microbiology), 2005-12, Vol.151 (Pt 12), p.3873

2005

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Experimental reproducibility in flow-chamber biofilms

Microbiology (Society for General Microbiology), 2000-10, Vol.146 ( Pt 10), p.2409

2000

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Abnormal visual gain control in a Parkinson's disease model

Human molecular genetics, 2014-09, Vol.23 (17), p.4465-4478

2014

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Identity and effects of quorum-sensing inhibitors produced by Penicillium species

Microbiology (Society for General Microbiology), 2005-05, Vol.151 (Pt 5), p.1325

2005

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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8945-8962

2017

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The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

Microbiology (Society for General Microbiology), 2001-09, Vol.147 (Pt 9), p.2517

2001

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The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4500-4505

2017

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Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6386-6397

2010

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Quorum Sensing Regulation in Aeromonas hydrophila

Journal of molecular biology, 2010-03, Vol.396 (4), p.849-857

2010

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Nonmucoid Pseudomonas aeruginosa Expresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse Model

The Journal of infectious diseases, 2005-08, Vol.192 (3), p.410-419

2005

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Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Frontiers in cellular neuroscience, 2016-06, Vol.10, p.164-164

2016

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Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation

Journal of medical microbiology, 2004-07, Vol.53 (7), p.679-690

2004

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Quorum sensing : a novel target for the treatment of biofilm infections

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2003-01, Vol.17 (4), p.241-250

2003

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3275-3278

2009

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Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6386-6397

2010

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Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa

Microbiology (Society for General Microbiology), 2000-10, Vol.146 ( Pt 10), p.2481

2000

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Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.5134-5140

2012

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Discovery of a potent and brain penetrant mGluRS positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (12), p.3275-3278

2009

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Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Antimicrobial agents and chemotherapy, 2007-10, Vol.51 (10), p.3677-3687

2007

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Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cjk-/- mice

Antimicrobial agents and chemotherapy, 2007, Vol.51 (10), p.3677-3687

2007

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Antisense silencing of the creA gene in Aspergillus nidulans

Applied and environmental microbiology, 2000-10, Vol.66 (10), p.4579-4581

2000

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Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

Experimental reproducibility in flow-chamber biofilms

Abnormal visual gain control in a Parkinson's disease model

Identity and effects of quorum-sensing inhibitors produced by Penicillium species

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Quorum Sensing Regulation in Aeromonas hydrophila

Nonmucoid Pseudomonas aeruginosa Expresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse Model

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation

Quorum sensing : a novel target for the treatment of biofilm infections

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential

Discovery of a potent and brain penetrant mGluRS positive allosteric modulator

Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cjk-/- mice

Antisense silencing of the creA gene in Aspergillus nidulans

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