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Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists

Bioorganic & medicinal chemistry, 2013-04, Vol.21 (7), p.2045-2055

2013

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A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice

Metabolism, clinical and experimental, 2016, Vol.65 (1), p.16-25

2016

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Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation

The Journal of pharmacology and experimental therapeutics, 2014-04, Vol.349 (1), p.66-74

2014

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Enhanced Tissue Expression and Elevated Circulating Level of Phospholipase A2 Receptor during Murine Endotoxic Shock

Archives of biochemistry and biophysics, 2000-07, Vol.379 (1), p.7-17

2000

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Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones

Bioorganic & medicinal chemistry, 2013-06, Vol.21 (11), p.3154-3163

2013

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Thromboxane A2: its generation and role in platelet activation

Progress in lipid research, 1989, Vol.28 (4), p.273-301

1989

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Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells

Biochemical pharmacology, 1990-12, Vol.40 (11), p.2535-2542

1990

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Mammalian Phospholipase A2

Biological & pharmaceutical bulletin, 2004-08, Vol.27 (8), p.1165

Hanasaki, Kohji

2004

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Identification of a Soluble Form Phospholipase A2Receptor as a Circulating Endogenous Inhibitor for Secretory Phospholipase A2

The Journal of biological chemistry, 2002-04, Vol.277 (16), p.13583-13588

2002

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Novel binding sites of 15-deoxy-Δ12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons

Experimental cell research, 2003-11, Vol.291 (1), p.212-227

2003

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Abstract 9795: Deficiency of Phospholipase A 2 Receptor Exacerbates Airway Inflammation and Pulmonary Vessel Remodeling After Ovalbumin Treatment Through Impaired Clearance of Secretory Phospholipase A 2

Circulation (New York, N.Y.), 2013-11, Vol.128 (suppl_22)

2013

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Effect of pancreatic type phospholipase A2 on isolated porcine cerebral arteries via its specific binding sites

FEBS letters, 1992-09, Vol.309 (3), p.261-264

1992

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S3G-27-4 A potent and selective neuropeptide Y Y5 receptor antagonist, S-2367 as an anti-obesity agent

Journal of Pharmacological Sciences, 2010, Vol.112 (suppl), p.41-41

2010

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Lack of Phospholipase A 2 Receptor Increases Susceptibility to Cardiac Rupture After Myocardial Infarction

Circulation research, 2014-01, Vol.114 (3), p.493-504

2014

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Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4631-4634

2010

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2 -Arylimino -5,6 -dihydro -4H-1,3 -thiazines as a new class of cannabinoid receptor agonists. Part 2 Orally bioavailable compounds

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3925-3929

2007

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Irbesartan enhances GLUT4 translocation and glucose transport in skeletal muscle cells

European journal of pharmacology, 2010-12, Vol.649 (1), p.23-28

2010

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Group X secretory PLA 2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

American journal of physiology. Heart and circulatory physiology, 2012-01, Vol.302 (1), p.H95-H104

2012

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Group X secretory PLA^sub 2^ in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

American journal of physiology. Heart and circulatory physiology, 2012-01, Vol.302 (1), p.H95

2012

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Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

American journal of physiology. Heart and circulatory physiology, 2012, Vol.71 (1)

2012

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Biological functions of group X secretory PLA2

Advances in experimental medicine and biology, 2003, Vol.525, p.93

2003

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Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

American Journal of Physiology: Cell Physiology, 2012-01, Vol.302 (1), p.H95-H104

2012

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Abstract 419: Human ApoB100/CETP Transgenic Mouse is a Useful Animal Model for Evaluation of HDL-C Elevation and Suppression of Atherosclerosis by Peroxisome Proliferator-Activated Receptor Delta Agonist

Circulation (New York, N.Y.), 2008-10, Vol.118 (suppl_18)

2008

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Differences between group X and group V secretory phospholipase A(2) in lipolytic modification of lipoproteins

Cellular & molecular biology letters, 2012-09, Vol.17 (3), p.459-478

2012

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Group V and X secretory phospholipase A(2)s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functions

Biochimica et biophysica acta, 2003-10, Vol.1642 (3), p.129

2003

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Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists

A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice

Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation

Enhanced Tissue Expression and Elevated Circulating Level of Phospholipase A2 Receptor during Murine Endotoxic Shock

Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones

Thromboxane A2: its generation and role in platelet activation

Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells

Mammalian Phospholipase A2

Identification of a Soluble Form Phospholipase A2Receptor as a Circulating Endogenous Inhibitor for Secretory Phospholipase A2

Novel binding sites of 15-deoxy-Δ12,14-prostaglandin J2 in plasma membranes from primary rat cortical neurons

Abstract 9795: Deficiency of Phospholipase A 2 Receptor Exacerbates Airway Inflammation and Pulmonary Vessel Remodeling After Ovalbumin Treatment Through Impaired Clearance of Secretory Phospholipase A 2

Effect of pancreatic type phospholipase A2 on isolated porcine cerebral arteries via its specific binding sites

S3G-27-4 A potent and selective neuropeptide Y Y5 receptor antagonist, S-2367 as an anti-obesity agent

Lack of Phospholipase A 2 Receptor Increases Susceptibility to Cardiac Rupture After Myocardial Infarction

Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution

2 -Arylimino -5,6 -dihydro -4H-1,3 -thiazines as a new class of cannabinoid receptor agonists. Part 2 Orally bioavailable compounds

Irbesartan enhances GLUT4 translocation and glucose transport in skeletal muscle cells

Group X secretory PLA 2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

Group X secretory PLA^sub 2^ in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

Biological functions of group X secretory PLA2

Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice

Abstract 419: Human ApoB100/CETP Transgenic Mouse is a Useful Animal Model for Evaluation of HDL-C Elevation and Suppression of Atherosclerosis by Peroxisome Proliferator-Activated Receptor Delta Agonist

Differences between group X and group V secretory phospholipase A(2) in lipolytic modification of lipoproteins

Group V and X secretory phospholipase A(2)s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functions

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