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EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons

Frontiers in neuroscience, 2024-02, Vol.18, p.1348478-1348478

2024

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Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

Neurobiology of disease, 2009-11, Vol.36 (2), p.374-383

2009

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Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis

Molecular genetics and metabolism reports, 2019-12, Vol.21, p.100513-100513, Article 100513

2019

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Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons

International journal of molecular sciences, 2022-12, Vol.23 (24), p.16013

2022

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Social media use by cardiovascular healthcare professionals in Portugal

Revista portuguesa de cardiologia, 2023-04, Vol.42 (4), p.349-357

2023

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Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s Disease

Pharmaceutics, 2024-05, Vol.16 (6), p.710

2024

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[18F]Fluoropyridine‐losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors

Journal of labelled compounds & radiopharmaceuticals, 2023-03, Vol.66 (3), p.73-85

2023

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Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

Cell reports (Cambridge), 2012-10, Vol.2 (4), p.789-798

2012

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Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Molecular therapy. Methods & clinical development, 2018-12, Vol.11, p.65-72

2018

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Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy

Molecular therapy, 2013-07, Vol.21 (7), p.1306-1315

2013

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Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Acta neuropathologica communications, 2020-08, Vol.8 (1), p.127-14, Article 127

2020

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Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model

Neurobiology of disease, 2015-10, Vol.82, p.22-31

2015

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AAVrh10 vector corrects pathology in animal models of GM1 gangliosidosis and achieves widespread distribution in the CNS of nonhuman primates

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.281-292

2022

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AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival

PloS one, 2010-10, Vol.5 (10), p.e13468-e13468

2010

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Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101122-101122, Article 101122

2023

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Hypothalamic dysfunction of the thrombospondin receptor α2δ-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency

The Journal of neuroscience, 2014-01, Vol.34 (2), p.554-565

2014

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Production of High-Titer Retrovirus and Lentivirus Vectors

Cold Spring Harbor protocols, 2018-04, Vol.2018 (4)

2018

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Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1

Molecular therapy. Methods & clinical development, 2019-12, Vol.15, p.18-26

2019

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Titration of Lentivirus Vectors

Cold Spring Harbor protocols, 2018-04, Vol.2018 (4)

2018

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Triple Bioluminescence Imaging for In Vivo Monitoring of Cellular Processes

Molecular therapy. Nucleic acids, 2013, Vol.2 (6), p.e99-e99, Article e99

2013

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Real-time MR tracking of AAV gene therapy with βgal-responsive MR probe in a murine model of GM1-gangliosidosis

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.128-134

2021

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A vida de Santo Ildefonso e o imaginário ligado ao culto Mariano no Reino Visigodo de Toledo (séculos VII-VIII)nto Ildefonso e o imaginário ligado ao culto mariano no Reino Visigodo de Toledo ( séculos VII- VIII)

Acta Scientiarum : education, 2019-10, Vol.41 (1), p.e48156

Esteves, Germano Miguel Favaro

2019

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7T MRI Predicts Amelioration of Neurodegeneration in the Brain after AAV Gene Therapy

Molecular therapy. Methods & clinical development, 2020-06, Vol.17, p.258-270

2020

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Experimental validation of the Betti’s Analytical Method for Double Glass Units

Engineering structures, 2024-09, Vol.315, p.118468, Article 118468

2024

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AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System

ASN neuro, 2015-04, Vol.7 (2), p.175909141556990

2015

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EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons

Social media use by cardiovascular healthcare professionals in Portugal

Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s Disease

[18F]Fluoropyridine‐losartan: A new approach toward human Positron Emission Tomography imaging of Angiotensin II Type 1 receptors

Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model

AAVrh10 vector corrects pathology in animal models of GM1 gangliosidosis and achieves widespread distribution in the CNS of nonhuman primates

AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival

Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model

Hypothalamic dysfunction of the thrombospondin receptor α2δ-1 underlies the overeating and obesity triggered by brain-derived neurotrophic factor deficiency

Production of High-Titer Retrovirus and Lentivirus Vectors

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1

Titration of Lentivirus Vectors

Triple Bioluminescence Imaging for In Vivo Monitoring of Cellular Processes

Real-time MR tracking of AAV gene therapy with βgal-responsive MR probe in a murine model of GM1-gangliosidosis

A vida de Santo Ildefonso e o imaginário ligado ao culto Mariano no Reino Visigodo de Toledo (séculos VII-VIII)nto Ildefonso e o imaginário ligado ao culto mariano no Reino Visigodo de Toledo ( séculos VII- VIII)

7T MRI Predicts Amelioration of Neurodegeneration in the Brain after AAV Gene Therapy

Experimental validation of the Betti’s Analytical Method for Double Glass Units

AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System

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