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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2911-2915

2011

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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4097-4101

2009

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2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4833-4837

2008

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β₃ adrenergic receptor agonists

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1865-1870

2011

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Heterocyclic acetamide and benzamide derivatives as potent and selective β3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1895-1899

2010

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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4579-4583

2007

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Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3048-3052

2005

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Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (20), p.5151-5155

2004

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Discovery of imidazole carboxamides as potent and selective CCK1R agonists

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4393-4396

2008

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4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.43-46

2004

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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3983-3987

2003

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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1346-1349

2006

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Discovery of 5‑{4-[(7-Ethyl-6-oxo‑5,6-dihydro‑1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}‑N‑methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14498-14512

2021

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Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B

Acta crystallographica. Section D, Biological crystallography., 2004-01, Vol.60 (1), p.169-171

2004

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Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 1. A Solution to the Problem of Chirality Merger during Elaboration of the Entire Carbotricyclic Framework

Journal of organic chemistry, 1999-04, Vol.64 (9), p.3244-3254

1999

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Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 2. Functionalization of Advanced Polycyclic Precursors to the 9-Epi and 8,9-Dehydro Congeners

Journal of organic chemistry, 1999-04, Vol.64 (9), p.3255-3265

1999

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A concise route to the tetracyclic core of phorbol

Tetrahedron, 1994-04, Vol.50 (14), p.4071-4086

1994

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Conformational Analysis of Poly(spirotetrahydrofuranyl)cyclohexyl Systems. The Preference of Multiple C−O Bonds for Equatorial Occupancy

Journal of the American Chemical Society, 1996-05, Vol.118 (18), p.4504-4505

1996

Volltextzugriff (PDF)

Analysis of the Conformational Nature, Resolvability, and Thermal Racemization of Hetero 2,3-Dispiro Cyclohexanones. The Weighting of Carbonyl/C-X Stabilization Relative to the Electronic Interaction between the Vicinal Electronegative Substituents

Journal of the American Chemical Society, 1994-01, Vol.116 (2), p.506-513

1994

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human beta sub(3 adrenergic receptor agonists)

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1865-1870

2011

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (6), p.1865-1870

2011

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Heterocyclic acetamide and benzamide derivatives as potent and selective b sub(3)-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.1895-1899

2010

Volltextzugriff (PDF)

Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (6), p.1895-1899

2010

Volltextzugriff (PDF)

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Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β₃ adrenergic receptor agonists

Heterocyclic acetamide and benzamide derivatives as potent and selective β3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

Potent and selective proline derived dipeptidyl peptidase IV inhibitors

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors

Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

Discovery of 5‑{4-[(7-Ethyl-6-oxo‑5,6-dihydro‑1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}‑N‑methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B

Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 1. A Solution to the Problem of Chirality Merger during Elaboration of the Entire Carbotricyclic Framework

Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 2. Functionalization of Advanced Polycyclic Precursors to the 9-Epi and 8,9-Dehydro Congeners

Discovery of Vibegron: A Potent and Selective β 3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

A concise route to the tetracyclic core of phorbol

Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β 3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Conformational Analysis of Poly(spirotetrahydrofuranyl)cyclohexyl Systems. The Preference of Multiple C−O Bonds for Equatorial Occupancy

Analysis of the Conformational Nature, Resolvability, and Thermal Racemization of Hetero 2,3-Dispiro Cyclohexanones. The Weighting of Carbonyl/C-X Stabilization Relative to the Electronic Interaction between the Vicinal Electronegative Substituents

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human beta sub(3 adrenergic receptor agonists)

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Heterocyclic acetamide and benzamide derivatives as potent and selective b sub(3)-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

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