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Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

Toxicological sciences, 2016-07, Vol.152 (1), p.214-229

2016

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A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

Scientific reports, 2016-06, Vol.6 (1), p.27239, Article 27239

2016

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A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients

Toxicological sciences, 2020-02, Vol.173 (2), p.229-243

2020

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Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

Scientific reports, 2018-07, Vol.8 (1), p.10606-15, Article 10606

2018

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Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

Archives of toxicology, 2021-09, Vol.95 (9), p.3049-3062

2021

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Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5203

2024

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Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs

Toxicological sciences, 2012-05, Vol.127 (1), p.187-198

2012

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Allergic hepatitis induced by drugs

Current opinion in allergy and clinical immunology, 2006-08, Vol.6 (4), p.258-265

2006

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Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data

Analytica chimica acta, 2024-01, Vol.1286, p.342052-342052, Article 342052

2024

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LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

Electrophoresis, 2015-09, Vol.36 (18), p.2294-2302

2015

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Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

Archives of toxicology, 2019-02, Vol.93 (2), p.519-532

2019

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A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies

Stem cell research & therapy, 2023-04, Vol.14 (1), p.94-94, Article 94

2023

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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Archives of toxicology, 2019-06, Vol.93 (6), p.1609-1637

2019

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Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector

Stem cell research & therapy, 2019-11, Vol.10 (1), p.317-317, Article 317

2019

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In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay

Toxicology letters, 2022-09, Vol.368, p.33-46

2022

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Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction

Journal of hepatology, 2014-09, Vol.61 (3), p.564-574

2014

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Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients

Nutrients, 2023-07, Vol.15 (14), p.3187

2023

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Comparing in vitro human liver models to in vivo human liver using RNA-Seq

Archives of toxicology, 2021-02, Vol.95 (2), p.573-589

2021

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In Vitro Methods in Pharmaceutical Research

1, 1996

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Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

Archives of toxicology, 2018-01, Vol.92 (1), p.383-399

2018

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A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs

Clinical pharmacology and therapeutics, 2021-11, Vol.110 (5), p.1293-1301

2021

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High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay

Journal of biomolecular screening, 2012-03, Vol.17 (3), p.394-400

2012

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Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis

The American journal of pathology, 2018-12, Vol.188 (12), p.2800-2810

2018

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Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

Archives of toxicology, 2018-12, Vol.92 (12), p.3505-3515

2018

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High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

Archives of toxicology, 2015-10, Vol.89 (10), p.1847-1860

2015

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Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients

Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers

Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

Drug-Induced Fatty Liver Disease (DIFLD): A Comprehensive Analysis of Clinical, Biochemical, and Histopathological Data for Mechanisms Identification and Consistency with Current Adverse Outcome Pathways

Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs

Allergic hepatitis induced by drugs

Cluster-Partial Least Squares (c-PLS) regression analysis: Application to miRNA and metabolomic data

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector

In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction

Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

In Vitro Methods in Pharmaceutical Research

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury

A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs

High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay

Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Nonalcoholic Fatty Liver Pathogenesis

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

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