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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2022-04, Vol.61, p.128607-128607, Article 128607

2022

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Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

Bioorganic & medicinal chemistry letters, 2008-09, Vol.18 (18), p.5023-5026

2008

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Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist

ACS medicinal chemistry letters, 2023-04, Vol.14 (4), p.442-449

2023

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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

Nature chemical biology, 2016-06, Vol.12 (6), p.444-451

2016

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Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3231-3235

2018

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Sequence-specific DNA recognition by polyamides

Current Opinion in Chemical Biology, 1999-12, Vol.3 (6), p.688-693

1999

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An efficient and scalable process to produce morpholine-d8

Synthetic communications, 2017-03, Vol.47 (5), p.481-485

2017

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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3713-3718

2006

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1253-1257

2004

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Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.3925-3928

2008

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Neurodegenerative Diseases

Dominguez, Celia

1. Aufl., 2010

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1259-1263

2004

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Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

ACS medicinal chemistry letters, 2011-02, Vol.2 (2), p.102-106

2011

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1253-1257

2004

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Development of small-molecule therapies for autoimmune diseases

Autoimmunity (Chur, Switzerland), 2010-11, Vol.43 (7), p.526-538

2010

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DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3914-3929

2003

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Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4137-4141

2008

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DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4352-4355

2004

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Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

Cell reports. Medicine, 2023-03, Vol.4 (3), p.100957, Article 100957

2023

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DNA Binding Ligands with Excellent Antibiotic Potency Against Drug-Resistant Gram-Positive Bacteria

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (18), p.2591-2594

2002

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DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2067-2072

2004

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1259-1263

2004

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An efficient and scalable process to produce morpholine-d 8

Synthetic communications, 2017-03, Vol.47 (5), p.481-485

2017

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An efficient synthesis of 1,6- and 1,7-dibromo-3-aminoisoquinolines: versatile templates for the preparation of functionalized isoquinolines

Tetrahedron letters, 2007-01, Vol.48 (3), p.487-489

2007

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Modulating N- versus O-arylation in pyrazolone-aryl halide couplings

Tetrahedron letters, 2008-01, Vol.49 (5), p.794-798

2008

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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist

A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Sequence-specific DNA recognition by polyamides

An efficient and scalable process to produce morpholine-d8

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

Neurodegenerative Diseases

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Development of small-molecule therapies for autoimmune diseases

DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology

Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases

DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

DNA Binding Ligands with Excellent Antibiotic Potency Against Drug-Resistant Gram-Positive Bacteria

DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

An efficient and scalable process to produce morpholine-d 8

An efficient synthesis of 1,6- and 1,7-dibromo-3-aminoisoquinolines: versatile templates for the preparation of functionalized isoquinolines

Modulating N- versus O-arylation in pyrazolone-aryl halide couplings

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