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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Annual review of biochemistry, 2016-06, Vol.85 (1), p.375-404

2016

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Nature chemical biology, 2011-05, Vol.7 (5), p.285

2011

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Targeting a neoantigen derived from a common TP53 mutation

Science (American Association for the Advancement of Science), 2021-03, Vol.371 (6533)

2021

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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Nature (London), 2016-01, Vol.529 (7587), p.541-545

2016

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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Nature (London), 2017-05, Vol.545 (7653), p.229-233

2017

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DAXX represents a new type of protein-folding enabler

Nature (London), 2021-09, Vol.597 (7874), p.132-137

2021

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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Nature communications, 2021-06, Vol.12 (1), p.3962-24, Article 3962

2021

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p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept

International journal of molecular sciences, 2016-11, Vol.17 (11), p.1874-1874

Uversky, Vladimir N

2016

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Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis

Cancer science, 2018-11, Vol.109 (11), p.3376-3382

2018

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Allele-Specific p53 Mutant Reactivation

Cancer cell, 2012-05, Vol.21 (5), p.614-625

2012

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The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases

International journal of molecular sciences, 2019-12, Vol.20 (24), p.6257

2019

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Targeting Biomolecular Condensation and Protein Aggregation against Cancer

Chemical reviews, 2023-07, Vol.123 (14), p.9094-9138

2023

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p53 is regulated by the lysine demethylase LSD1

Nature, 2007-09, Vol.449 (7158), p.105-108

2007

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MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8), p.2587-2597

2013

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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (18), p.8859-8868

2019

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Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

Biopolymers, 2016-07, Vol.106 (4), p.598-612

2016

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Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

Nature communications, 2013-01, Vol.4 (1), p.1407-1407, Article 1407

2013

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Structural insights into the functional mechanism of the ubiquitin ligase E6AP

Nature communications, 2024-04, Vol.15 (1), p.3531-3531, Article 3531

2024

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The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment

Apoptosis (London), 2024-06, Vol.29 (5-6), p.865-881

2024

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Tuning the Binding Affinity and Selectivity of Perfluoroaryl‐Stapled Peptides by Cysteine‐Editing

Chemistry : a European journal, 2019-01, Vol.25 (1), p.177-182

2019

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

Oncogene, 2007-04, Vol.26 (15), p.2226-2242

2007

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Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

Oncogene, 2010-08, Vol.29 (31), p.4378-4387

2010

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Structural biology of the tumor suppressor p53

Annual review of biochemistry, 2008-01, Vol.77 (1), p.557-582

2008

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (12), p.4665-4670

2009

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Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

Oncogene, 2007-08, Vol.26 (35), p.5029-5037

2007

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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Targeting a neoantigen derived from a common TP53 mutation

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

DAXX represents a new type of protein-folding enabler

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept

Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis

Allele-Specific p53 Mutant Reactivation

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases

Targeting Biomolecular Condensation and Protein Aggregation against Cancer

p53 is regulated by the lysine demethylase LSD1

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

Structural insights into the functional mechanism of the ubiquitin ligase E6AP

The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment

Tuning the Binding Affinity and Selectivity of Perfluoroaryl‐Stapled Peptides by Cysteine‐Editing

Structure-function-rescue: the diverse nature of common p53 cancer mutants

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

Structural biology of the tumor suppressor p53

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

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