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Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer

ACS nano, 2019-11, Vol.13 (11), p.12511-12524

2019

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Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels

Brain research, 2024-12, Vol.1845, p.149203, Article 149203

2024

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Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway

Phytomedicine (Stuttgart), 2023-01, Vol.108, p.154528-154528, Article 154528

2023

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Sesquiterpene lactones improve secretory diarrhea symptoms by inhibiting intestinal Ca2+-activated Cl– channel activities directly and indirectly

European journal of pharmacology, 2023-09, Vol.955, p.175917-175917, Article 175917

2023

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Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer

Frontiers in pharmacology, 2021-11, Vol.12, p.781033-781033

2021

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Development of alantolactone-loaded zein and shellac nanoparticles for controlled release in simulated gastrointestinal digestion

Journal of food engineering, 2023-12, Vol.358, p.111664, Article 111664

2023

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Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Frontiers in pharmacology, 2021-09, Vol.12, p.730312-730312

2021

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Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone

European journal of medicinal chemistry, 2022-10, Vol.240, p.114574-114574, Article 114574

2022

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A comprehensive review of anticancer mechanisms of action of Alantolactone

Biomedicine & pharmacotherapy, 2021-04, Vol.136, p.111231-111231, Article 111231

2021

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Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells

Frontiers in pharmacology, 2022-02, Vol.13, p.795613

2022

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Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Respiratory research, 2020-04, Vol.21 (1), p.95-11, Article 95

2020

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Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway

Archives of Pharmacal Research, 2018, 41(3), , pp.299-313

2018

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Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments

Journal of ethnopharmacology, 2018-03, Vol.213, p.256-261

2018

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Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice

British journal of pharmacology, 2023-06, Vol.180 (12), p.1634-1647

2023

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Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-11, Vol.1211, p.123458-123458, Article 123458

2022

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Alantolactone induces apoptosis in THP‐1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway

Chemical biology & drug design, 2021-02, Vol.97 (2), p.266-272

2021

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Alantolactone induces platelet apoptosis by activating the Akt pathway

Platelets (Edinburgh), 2023-12, Vol.34 (1), p.2173505-2173505

2023

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Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway

Free radical research, 2019-01, Vol.53 (1), p.104-114

2019

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Alantolactone suppresses APOC3 expression and alters lipid homeostasis in L02 liver cells

European journal of pharmacology, 2018-06, Vol.828, p.60-66

2018

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Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

Biochemical pharmacology, 2016-02, Vol.102, p.34-44

2016

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Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone

European journal of pharmacology, 2024-04, Vol.969, p.176458-176458, Article 176458

2024

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Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation

Cancer science, 2021-10, Vol.112 (10), p.4303-4316

2021

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Alantolactone Enhances the Phagocytic Properties of Human Macrophages and Modulates Their Proinflammatory Functions

Frontiers in pharmacology, 2020-09, Vol.11, p.1339-1339

2020

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Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

Chemical biology & drug design, 2021-12, Vol.98 (6), p.1131-1145

2021

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Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB

Toxicology and applied pharmacology, 2018-10, Vol.356, p.159-171

2018

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Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer

Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels

Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway

Sesquiterpene lactones improve secretory diarrhea symptoms by inhibiting intestinal Ca2+-activated Cl– channel activities directly and indirectly

Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer

Development of alantolactone-loaded zein and shellac nanoparticles for controlled release in simulated gastrointestinal digestion

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone

A comprehensive review of anticancer mechanisms of action of Alantolactone

Sesquiterpene Lactones Attenuate Paclitaxel Resistance Via Inhibiting MALAT1/STAT3/ FUT4 Axis and P-Glycoprotein Transporters in Lung Cancer Cells

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway

Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments

Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice

Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia

Alantolactone induces apoptosis in THP‐1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway

Alantolactone induces platelet apoptosis by activating the Akt pathway

Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway

Alantolactone suppresses APOC3 expression and alters lipid homeostasis in L02 liver cells

Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone

Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation

Alantolactone Enhances the Phagocytic Properties of Human Macrophages and Modulates Their Proinflammatory Functions

Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB

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