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Structure-activity relationships of GPR120 agonists based on a docking simulation

Molecular pharmacology, 2010-11, Vol.78 (5), p.804-810

2010

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Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Bioorganic & medicinal chemistry letters, 2014-07, Vol.24 (14), p.3100-3103

2014

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Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Expert opinion on investigational drugs, 2016-08, Vol.25 (8), p.871-890

2016

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The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

EMBO molecular medicine, 2018-03, Vol.10 (3), p.n/a

2018

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Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis

Biomedicine & pharmacotherapy, 2020-06, Vol.126, p.110056, Article 110056

2020

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Free fatty acid receptor 4 (FFA4) activation attenuates obese asthma by suppressing adiposity and resolving metaflammation

Biomedicine & pharmacotherapy, 2024-05, Vol.174, p.116509-116509, Article 116509

2024

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A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice

Biomedicine & pharmacotherapy, 2021-07, Vol.139, p.111613-111613, Article 111613

2021

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Phytosphingosine is a novel activator of GPR120

Journal of biochemistry (Tokyo), 2018-07, Vol.164 (1), p.27-32

2018

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Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

British journal of pharmacology, 2006-07, Vol.148 (5), p.619-628

2006

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Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

International journal of molecular sciences, 2024-06, Vol.25 (11), p.5866

2024

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Agonism of GPR120 prevents ox-LDL-induced attachment of monocytes to endothelial cells

Chemico-biological interactions, 2020-01, Vol.316, p.108916, Article 108916

2020

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A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation

Life sciences (1973), 2021-03, Vol.269, p.119029-119029, Article 119029

2021

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Targeting FFA1 and FFA4 receptors in cancer-induced cachexia

American journal of physiology: endocrinology and metabolism, 2020-11, Vol.319 (5), p.E877-E892

2020

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GPR120 agonists for the treatment of diabetes: a patent review (2014 present)

Expert opinion on therapeutic patents, 2020-10, Vol.30 (10), p.729-742

2020

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Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells

International immunopharmacology, 2021-08, Vol.97, p.107698-107698, Article 107698

2021

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Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Chemistry & biodiversity, 2023-01, Vol.20 (1), p.e202200814-n/a

2023

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Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells

Experimental cell research, 2016-03, Vol.342 (2), p.193-199

2016

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Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.841-846

2018

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Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats

Journal of neuroinflammation, 2020-04, Vol.17 (1), p.129-129, Article 129

2020

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Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

Biochemical and biophysical research communications, 2010-06, Vol.396 (4), p.1030-1035

2010

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Novel selective ligands for free fatty acid receptors GPR120 and GPR40

Naunyn-Schmiedeberg's archives of pharmacology, 2009-09, Vol.380 (3), p.247-255

2009

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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1278-1283

2017

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Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells

Diabetes, obesity & metabolism, 2014-11, Vol.16 (11), p.1128-1139

2014

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Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3272-3278

2017

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Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats

Biomedicine & pharmacotherapy, 2019-09, Vol.117, p.109172-109172, Article 109172

2019

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Structure-activity relationships of GPR120 agonists based on a docking simulation

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat

Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis

Free fatty acid receptor 4 (FFA4) activation attenuates obese asthma by suppressing adiposity and resolving metaflammation

A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice

Phytosphingosine is a novel activator of GPR120

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

Agonism of GPR120 prevents ox-LDL-induced attachment of monocytes to endothelial cells

A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation

Targeting FFA1 and FFA4 receptors in cancer-induced cachexia

GPR120 agonists for the treatment of diabetes: a patent review (2014 present)

Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells

Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats

Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

Novel selective ligands for free fatty acid receptors GPR120 and GPR40

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells

Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats

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