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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7324-7333

2013

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BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Clinical cancer research, 2009-05, Vol.15 (9), p.3094-3102

2009

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Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2694-2709

2022

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Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Drug delivery, 2019-01, Vol.26 (1), p.756-764

2019

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Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-g]pteridines

Chemical and Pharmaceutical Bulletin, 2016/05/01, Vol.64(5), pp.476-482

2016

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Inhibition of Transforming Growth Factor-β Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage

Stroke (1970), 2014-03, Vol.45 (3), p.828-834

2014

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2048-2052

2009

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (9), p.2743-2749

2013

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Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties

Future medicinal chemistry, 2015-01, Vol.7 (14), p.1937-1951

2015

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Reversible and irreversible differentiation of cardiac fibroblasts

Cardiovascular research, 2014-03, Vol.101 (3), p.411

2014

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Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infarction

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4279-4294

2007

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Metabolism of vesatolimod in rat, dog, and human liver microsomes: Metabolic stability assessment, metabolite identification, and interspecies comparison

Drug testing and analysis, 2019-02, Vol.11 (2), p.240-249

2019

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BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Biochemical journal, 2007-01, Vol.401 (1), p.29-38

2007

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Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.4986-4989

2012

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Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis

The Journal of neuroscience, 2016-09, Vol.36 (37), p.9590-9603

2016

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Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters

The Journal of biological chemistry, 2011-08, Vol.286 (31), p.27111

2011

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Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay

Journal of lipid research, 2007-06, Vol.48 (6), p.1422-1427

2007

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TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

Journal of neuroinflammation, 2019-12, Vol.16 (1), p.262-19, Article 262

2019

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Polo‐like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma

Hepatology (Baltimore, Md.), 2013-10, Vol.58 (4), p.1362-1374

2013

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TGF-β regulates sclerostin expression via the ECR5 enhancer

Bone (New York, N.Y.), 2012-03, Vol.50 (3), p.663-669

2012

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Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression

European spine journal, 2015-09, Vol.24 (9), p.1959-1968

2015

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of medicinal chemistry, 2007-05, Vol.50 (9), p.2269-2272

2007

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Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro

European journal of pharmacology, 2013-05, Vol.708 (1-3), p.30-37

2013

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Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy

Brain (London, England : 1878), 2010-12, Vol.133 (12), p.3778-3794

2010

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Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation

Journal of neurosurgery. Spine, 2014-10, Vol.21 (4), p.653-661

2014

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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-g]pteridines

Inhibition of Transforming Growth Factor-β Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties

Reversible and irreversible differentiation of cardiac fibroblasts

Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infarction

Metabolism of vesatolimod in rat, dog, and human liver microsomes: Metabolic stability assessment, metabolite identification, and interspecies comparison

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis

Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters

Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay

TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

Polo‐like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma

TGF-β regulates sclerostin expression via the ECR5 enhancer

Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression

Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy

Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation

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