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Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

Cardiovascular research, 2000-09, Vol.47 (4), p.797-805

2000

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Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase

Circulation (New York, N.Y.), 2001-08, Vol.104 (9), p.979-981

2001

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Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction

Circulation (New York, N.Y.), 2001-01, Vol.103 (4), p.555-561

2001

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Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart

The Journal of biological chemistry, 2002-02, Vol.277 (8), p.6676-6681

2002

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Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway

The Journal of biological chemistry, 2001-08, Vol.276 (33), p.31133-31141

2001

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Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

Cardiovascular research, 2002-03, Vol.53 (4), p.936-943

2002

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Isolation and Characterization of the Murine Cardiotrophin-1 Gene: Expression and Norepinephrine-Induced Transcriptional Activation

Journal of molecular and cellular cardiology, 2000-07, Vol.32 (7), p.1275-1284

2000

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Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

FEBS letters, 2002-07, Vol.524 (1), p.123-126

2002

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Recent trends in autoimmune disease research

Nihon rinshō, 1988-04, Vol.46 (4), p.741

1988

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Trends in immunology

Nihon rinshō, 1983, Vol.41 (4), p.875

1983

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Angiotensin II Interferes with Leukemia Inhibitory Factor-Induced STAT3 Activation in Cardiac Myocytes

Biochemical and biophysical research communications, 1998-12, Vol.253 (1), p.147-150

1998

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Regulatory mechanism of autoantibody production in mice to bromelin-treated isologous red blood cells

Immunology, 1979-02, Vol.36 (2), p.257-264

1979

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Editorial Comment from Dr Negoro to Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats

International journal of urology, 2016-01, Vol.23 (1), p.99-100

Negoro, Hiromitsu

2016

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Chronobiology of Micturition: Putative Role of the Circadian Clock

The Journal of urology, 2013-09, Vol.190 (3), p.843-849

2013

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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.228-237

2011

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Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4266-4270

2014

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Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling

PloS one, 2014-08, Vol.9 (8), p.e106269-e106269

2014

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Xanthine oxidase-derived reactive oxygen species mediate 4-oxo-2-nonenal-induced hepatocyte cell death

Toxicology and applied pharmacology, 2010-12, Vol.249 (2), p.127-131

2010

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TAK‐875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β‐cell dysfunction in Zucker diabetic fatty rats

British journal of pharmacology, 2013-10, Vol.170 (3), p.568-580

2013

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Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.3960-3974

2012

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Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1365-1378

2011

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Effects of Biotin Deficiency on Biotinylated Proteins and Biotin-Related Genes in the Rat Brain

Journal of Nutritional Science and Vitaminology, 2016, Vol.62(2), pp.81-87

2016

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Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders

Chemical and Pharmaceutical Bulletin, 2017/11/01, Vol.65(11), pp.1058-1077

2017

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Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

Nature communications, 2012-05, Vol.3 (1), p.809-809, Article 809

2012

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Discovery and structure-activity relationships study of positive allosteric modulators of the M 3 muscarinic acetylcholine receptor

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (13), p.115531

2020

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Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase

Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart

Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway

Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

Isolation and Characterization of the Murine Cardiotrophin-1 Gene: Expression and Norepinephrine-Induced Transcriptional Activation

Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway

Recent trends in autoimmune disease research

Trends in immunology

Angiotensin II Interferes with Leukemia Inhibitory Factor-Induced STAT3 Activation in Cardiac Myocytes

Regulatory mechanism of autoantibody production in mice to bromelin-treated isologous red blood cells

Editorial Comment from Dr Negoro to Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats

Chronobiology of Micturition: Putative Role of the Circadian Clock

TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling

Xanthine oxidase-derived reactive oxygen species mediate 4-oxo-2-nonenal-induced hepatocyte cell death

TAK‐875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β‐cell dysfunction in Zucker diabetic fatty rats

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

Effects of Biotin Deficiency on Biotinylated Proteins and Biotin-Related Genes in the Rat Brain

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

Discovery and structure-activity relationships study of positive allosteric modulators of the M 3 muscarinic acetylcholine receptor

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