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MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans

Journal of psychopharmacology (Oxford), 2011-03, Vol.25 (3), p.314-328

2011

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θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (17), p.9891-9896

1999

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Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

Journal of psychopharmacology (Oxford), 2011-03, Vol.25 (3), p.329-344

2011

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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.17

2010

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Age-related changes in GABA A receptor subunit composition and function in rat auditory system

Neuroscience, 1999-01, Vol.93 (1), p.307-312

1999

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Initial sequence and comparative analysis of the cat genome

Genome Research, 2007-11, Vol.17 (11), p.1675-1689

2007

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3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1807-1822

2004

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L-Type Voltage-Gated Calcium Channels Are Involved in the in Vivo and in Vitro Expression of Fear Conditioning

Annals of the New York Academy of Sciences, 2003-04, Vol.985 (1), p.135-149

2003

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Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Molecular pharmacology, 2001-01, Vol.59 (1), p.144-152

2001

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Expression Cloning and Signaling Properties of the Rat Glucagon Receptor

Science (American Association for the Advancement of Science), 1993-03, Vol.259 (5101), p.1614-1616

1993

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Hippocampal Lesions Do Not Impair Negative Patterning: A Challenge to Configural Association Theory

Behavioral neuroscience, 1993-04, Vol.107 (2), p.227-234

1993

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Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N‐Methyl‐d‐Aspartate Receptor Subtypes

Journal of neurochemistry, 1996-06, Vol.66 (6), p.2239-2247

1996

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The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures

Brain research, 1990-10, Vol.531 (1), p.183-188

1990

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Uptake of glutathione by renal cortical mitochondria

Archives of biochemistry and biophysics, 1991-08, Vol.288 (2), p.653-663

1991

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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates

The Journal of pharmacology and experimental therapeutics, 2006-01, Vol.316 (1), p.410

2006

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The Pharmacology of the Benzodiazepine Site of the GABA-A Receptor is Dependent on the Type of γ-Subunit Present

Journal of receptors and signal transduction, 1995, Vol.15 (1-4), p.173-183

1995

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Carotenoid compound crocetin improves cerebral oxygenation in hemorrhaged rats

Journal of cerebral blood flow and metabolism, 1986-12, Vol.6 (6), p.703-707

1986

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Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3642-3657

2004

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3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels

Journal of medicinal chemistry, 2002-04, Vol.45 (9), p.1887-1900

2002

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Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain

Brain research, 1999-03, Vol.822 (1-2), p.265-270

1999

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines

The Journal of neuroscience, 2005-11, Vol.25 (46), p.10682-10688

2005

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Monoclonal antibodies to the human gamma 2 subunit of the GABAA/benzodiazepine receptors

Journal of neurochemistry, 1995-03, Vol.64 (3), p.1305-1311

1995

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MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans

θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit

Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

Age-related changes in GABA A receptor subunit composition and function in rat auditory system

Initial sequence and comparative analysis of the cat genome

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1

L-Type Voltage-Gated Calcium Channels Are Involved in the in Vivo and in Vitro Expression of Fear Conditioning

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Expression Cloning and Signaling Properties of the Rat Glucagon Receptor

Hippocampal Lesions Do Not Impair Negative Patterning: A Challenge to Configural Association Theory

Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N‐Methyl‐d‐Aspartate Receptor Subtypes

The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures

Uptake of glutathione by renal cortical mitochondria

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models

The Pharmacology of the Benzodiazepine Site of the GABA-A Receptor is Dependent on the Type of γ-Subunit Present

Carotenoid compound crocetin improves cerebral oxygenation in hemorrhaged rats

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site

3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels

Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines

Monoclonal antibodies to the human gamma 2 subunit of the GABAA/benzodiazepine receptors

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