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Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.122-132

2010

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Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2816-2825

2004

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Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Journal of medicinal chemistry, 2009-03, Vol.52 (5), p.1408-1415

2009

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Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2‑Monohalo and 2,8-Dihalo Derivatives

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.9773-9784

2012

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Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Molecular pharmacology, 2002-09, Vol.62 (3), p.628-637

2002

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Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore

The Journal of pharmacology and experimental therapeutics, 2008-08, Vol.326 (2), p.657-671

2008

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Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.4933-4945

2003

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Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo

Chemical research in toxicology, 2001-08, Vol.14 (8), p.965-974

2001

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Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

Chemical research in toxicology, 2000-11, Vol.13 (11), p.1075-1081

2000

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Synthesis, Antimalarial Activity, Biomimetic Iron(II) Chemistry, and in Vivo Metabolism of Novel, Potent C-10-Phenoxy Derivatives of Dihydroartemisinin

Journal of medicinal chemistry, 2001-01, Vol.44 (1), p.58-68

2001

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Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide: Synthesis, Reactivity, and Mechanistic Analysis

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.6165-6176

2007

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Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of α-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen–DNA adducts

Carcinogenesis (New York), 2000-10, Vol.21 (10), p.1851-1858

2000

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Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.271

2005

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α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

Carcinogenesis (New York), 1999-01, Vol.20 (1), p.153-160

1999

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Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor

Biochemical pharmacology, 2000-11, Vol.60 (10), p.1519-1530

2000

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Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene

Chemico-biological interactions, 2004-03, Vol.147 (2), p.173-184

2004

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Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay

The Journal of pharmacology and experimental therapeutics, 2001-02, Vol.296 (2), p.329

2001

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Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

British journal of pharmacology, 1998-09, Vol.125 (1), p.159-167

1998

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Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

Chemico-biological interactions, 2000-12, Vol.129 (3), p.279-295

2000

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The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

The Journal of pharmacology and experimental therapeutics, 1997-08, Vol.282 (2), p.795

1997

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The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide

Drug metabolism and disposition, 1997-10, Vol.25 (10), p.1200

1997

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Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation

The Journal of pharmacology and experimental therapeutics, 1999-04, Vol.289 (1), p.511

1999

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Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s)

Drug metabolism and disposition, 1996-04, Vol.24 (4), p.469

1996

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Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans

The Journal of pharmacology and experimental therapeutics, 2001-04, Vol.297 (1), p.103

2001

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Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century

Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2‑Monohalo and 2,8-Dihalo Derivatives

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore

Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound for N-tert-Butyl Isoquine

Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials

Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo

Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

Synthesis, Antimalarial Activity, Biomimetic Iron(II) Chemistry, and in Vivo Metabolism of Novel, Potent C-10-Phenoxy Derivatives of Dihydroartemisinin

Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide: Synthesis, Reactivity, and Mechanistic Analysis

Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of α-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen–DNA adducts

Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity

α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor

Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene

Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay

Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

The rat biliary metabolites of dihydroartemisinin, an antimalarial endoperoxide

Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation

Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s)

Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans

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