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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Cell death & disease, 2021-09, Vol.12 (9), p.824-14, Article 824

2021

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Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy

Cardiovascular research, 2015-01, Vol.105 (1), p.55-64

2015

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Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors

Molecular pharmacology, 2021-04, Vol.99 (4), p.294-307

2021

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The cAMP Binding Protein Epac Regulates Cardiac Myofilament Function

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (33), p.14144-14149

2009

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Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

The Journal of neuroscience, 2015-08, Vol.35 (32), p.11315-11329

2015

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Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC

Biomedicine & pharmacotherapy, 2021-11, Vol.143, p.112072, Article 112072

2021

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Epac enhances excitation–transcription coupling in cardiac myocytes

Journal of molecular and cellular cardiology, 2012-01, Vol.52 (1), p.283-291

2012

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The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

The Journal of physiology, 2007-09, Vol.583 (2), p.685-694

2007

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A Versatile Vector for Gene and Oligonucleotide Transfer into Cells in Culture and in vivo: Polyethylenimine

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (16), p.7297-7301

1995

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Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

Molecular pharmacology, 1997-04, Vol.51 (4), p.535-541

1997

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Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes

Journal of molecular and cellular cardiology, 2012-11, Vol.53 (5), p.617-625

2012

Volltextzugriff (PDF)

Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death

Circulation research, 2017-02, Vol.120 (4), p.645-657

2017

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Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect

Pflügers Archiv, 2010-09, Vol.460 (4), p.731-741

2010

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PKC-delta and PKC-epsilon: Foes of the same family or strangers?

Journal of molecular and cellular cardiology, 2011-11, Vol.51 (5), p.665-673

2011

Volltextzugriff (PDF)

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

Circulation research, 2008-04, Vol.102 (8), p.959-965

2008

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Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2214-2225

2009

Volltextzugriff (PDF)

cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy

Circulation research, 2005-12, Vol.97 (12), p.1296-1304

2005

Volltextzugriff (PDF)

Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca2+/Calmodulin-Dependent Protein Kinase II Signaling

Circulation (New York, N.Y.), 2015-01, Vol.131 (4), p.390-400

2015

Volltextzugriff (PDF)

Isolation of the serotoninergic 5‐HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6‐glial and CHO cell lines

British journal of pharmacology, 2000-02, Vol.129 (4), p.771-781

2000

Volltextzugriff (PDF)

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

Cellular signalling, 2013-04, Vol.25 (4), p.970-980

2013

Volltextzugriff (PDF)

The EGF receptor activates ERK but not JNK Ras-dependently in basal conditions but ERK and JNK activation pathways are predominantly Ras-independent during cardiomyocyte stretch

The international journal of biochemistry & cell biology, 2009-05, Vol.41 (5), p.1173-1181

2009

Volltextzugriff (PDF)

Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

Cellular signalling, 2010-10, Vol.22 (10), p.1459-1468

2010

Volltextzugriff (PDF)

VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux

Neuropharmacology, 2007-09, Vol.53 (4), p.563-573

2007

Volltextzugriff (PDF)

Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes

British journal of pharmacology, 1999-05, Vol.127 (1), p.65-74

1999

Volltextzugriff (PDF)

Design and Synthesis of Specific Probes for Human 5-HT4 Receptor Dimerization Studies

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6220-6228

2005

Volltextzugriff (PDF)

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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy

Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors

The cAMP Binding Protein Epac Regulates Cardiac Myofilament Function

Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC

Epac enhances excitation–transcription coupling in cardiac myocytes

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

A Versatile Vector for Gene and Oligonucleotide Transfer into Cells in Culture and in vivo: Polyethylenimine

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes

Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death

Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect

PKC-delta and PKC-epsilon: Foes of the same family or strangers?

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy

Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca2+/Calmodulin-Dependent Protein Kinase II Signaling

Isolation of the serotoninergic 5‐HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6‐glial and CHO cell lines

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

The EGF receptor activates ERK but not JNK Ras-dependently in basal conditions but ERK and JNK activation pathways are predominantly Ras-independent during cardiomyocyte stretch

Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux

Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes

Design and Synthesis of Specific Probes for Human 5-HT4 Receptor Dimerization Studies

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