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Kidney Slices of Human and Rat to Characterize Cisplatin-Induced Injury on Cellular Pathways and Morphology

Toxicologic pathology, 2004-09, Vol.32 (5), p.577-590

2004

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Organ Slice Viability Extended for Pathway Characterization: An in Vitro Model to Investigate Fibrosis

Toxicological sciences, 2004-12, Vol.82 (2), p.534-544

2004

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Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme a thioesters of hypolipidaemic drugs

Biochemical and biophysical research communications, 1989-03, Vol.159 (3), p.1026-1031

1989

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Use of primary cultures of adult rat hepatocytes to investigate mechanisms of action of nafenopin, a hepatocarcinogenic peroxisome proliferator

Carcinogenesis (New York), 1984-08, Vol.5 (8), p.1033-1039

1984

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Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method

Hepatology (Baltimore, Md.), 1990-02, Vol.11 (2), p.286-297

1990

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Nafenopin, a hypolipidemic and non-genotoxic hepatocarcinogen increases intracellular calcium and transiently decreases intracellular pH in hepatocytes without generation of inositol phosphates

Biochemical pharmacology, 1990-11, Vol.40 (10), p.2247-2257

1990

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Purification of rat liver epoxide hydratase to apparent homogeneity

FEBS letters, 1975-11, Vol.59 (2), p.291-295

1975

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Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism

Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Vol.17, p.209

1995

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Safety assessment of OTC drugs: doxylamine succinate

Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Vol.17, p.326

1995

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Developmental neurotoxicity of carbon monoxide

Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Vol.17, p.295

1995

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Changes in EEG of freely-moving rats caused by three-generation organophosphate treatment

Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Vol.17, p.288

1995

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Estrogenic effects of some xenobiotics

Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Vol.17, p.148

1995

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Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver

Carcinogenesis (New York), 1984-01, Vol.5 (1), p.41-46

1984

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Microsomal Metabolism of Benzene to Species Irreversibly Binding to Microsomal Protein and Effects of Modifications of This Metabolism

Molecular pharmacology, 1978-09, Vol.14 (5), p.920-929

1978

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Studies on the mechanism of induction of microsomal cytochrome P452 and peroxisomal bifunctional enzyme mRNAs by nafenopin in primary cultures of adult rat hepatocytes

Biochemical pharmacology, 1991-01, Vol.41 (2), p.310-312

1991

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Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide

Nature (London), 1976-01, Vol.259 (5538), p.53-55

1976

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Lack of covalent binding to DNA of di- n-octyltin dichloride (DOTC) in vivo and in vitro

Toxicology letters, 1990-02, Vol.50 (2), p.179-188

1990

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[46] Microsomal epoxide hydrolase

Methods in Enzymology, 1981, Vol.77, p.344-349

1981

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The effect of short term feeding of the antioxidant triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate on serum thyrotropin and thyroid hormones in the male rat

Toxicology and applied pharmacology, 1991, Vol.107 (1), p.129-140

1991

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Species differences in the toxicity of p-chloro- o-toluidine to rats and mice. Covalent binding to hepatic macromolecules and hepatic non-parenchymal cell DNA and an investigation of effects upon the incorporation of [ 3H] thymidine into capillary endothelial cells

Chemico-biological interactions, 1986, Vol.57 (1), p.27-40

1986

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Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons

Biochemical pharmacology, 1978, Vol.27 (1), p.17-20

1978

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Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase. A general assay and kinetic properties

European journal of biochemistry, 1976-10, Vol.69 (1), p.97-103

1976

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Endogenous role of epoxide-hydratase. Development of a steroid epoxide-hydratase assay and properties of the enzyme

European journal of biochemistry, 1979-06, Vol.97 (1), p.275-281

1979

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Synthesis and structure–activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4741-4744

2010

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Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7120-7123

2010

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Kidney Slices of Human and Rat to Characterize Cisplatin-Induced Injury on Cellular Pathways and Morphology

Organ Slice Viability Extended for Pathway Characterization: An in Vitro Model to Investigate Fibrosis

Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme a thioesters of hypolipidaemic drugs

Use of primary cultures of adult rat hepatocytes to investigate mechanisms of action of nafenopin, a hepatocarcinogenic peroxisome proliferator

Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: A stereological study using the nucleator method

Nafenopin, a hypolipidemic and non-genotoxic hepatocarcinogen increases intracellular calcium and transiently decreases intracellular pH in hepatocytes without generation of inositol phosphates

Purification of rat liver epoxide hydratase to apparent homogeneity

Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism

Safety assessment of OTC drugs: doxylamine succinate

Developmental neurotoxicity of carbon monoxide

Changes in EEG of freely-moving rats caused by three-generation organophosphate treatment

Estrogenic effects of some xenobiotics

Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver

Microsomal Metabolism of Benzene to Species Irreversibly Binding to Microsomal Protein and Effects of Modifications of This Metabolism

Studies on the mechanism of induction of microsomal cytochrome P452 and peroxisomal bifunctional enzyme mRNAs by nafenopin in primary cultures of adult rat hepatocytes

Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide

Lack of covalent binding to DNA of di- n-octyltin dichloride (DOTC) in vivo and in vitro

[46] Microsomal epoxide hydrolase

The effect of short term feeding of the antioxidant triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate on serum thyrotropin and thyroid hormones in the male rat

Species differences in the toxicity of p-chloro- o-toluidine to rats and mice. Covalent binding to hepatic macromolecules and hepatic non-parenchymal cell DNA and an investigation of effects upon the incorporation of [ 3H] thymidine into capillary endothelial cells

Specificity of human, rat and mouse skin epoxide hydratase towards K-region epoxides of polycyclic hydrocarbons

Epoxides derived from various polycyclic hydrocarbons as substrates of homogeneous and microsome-bound epoxide hydratase. A general assay and kinetic properties

Endogenous role of epoxide-hydratase. Development of a steroid epoxide-hydratase assay and properties of the enzyme

Synthesis and structure–activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists

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