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Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer’s Disease Brain

ACS chemical neuroscience, 2016-07, Vol.7 (7), p.897-911

2016

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Assessment of angiotensin II receptor blockade in humans using a standardized angiotensin II receptor-binding assay

American journal of hypertension, 1999-12, Vol.12 (12), p.1201-1208

1999

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High-affinity [ 3H] kainic acid binding to brain membranes : a re-evaluation of ligand potency and selectivity

Journal of pharmacological and toxicological methods, 1999-11, Vol.42 (3), p.121-125

1999

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Evaluating kratom alkaloids using PHASE

PloS one, 2020-03, Vol.15 (3), p.e0229646

2020

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A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

Journal of cerebral blood flow and metabolism, 2013-01, Vol.33 (1), p.53-58

2013

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Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3206-3221

2011

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Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease

PloS one, 2012-03, Vol.7 (3), p.e31310

2012

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Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Journal of medicinal chemistry, 2012-10, Vol.55 (19), p.8211-8224

2012

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Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4671-4690

2013

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The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium

The Journal of pharmacology and experimental therapeutics, 2012-11, Vol.343 (2), p.520

2012

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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (37), p.15950-15955

2009

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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

The Journal of pharmacology and experimental therapeutics, 2013-01, Vol.344 (1), p.196

2013

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Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor

Molecular pharmacology, 2012-11, Vol.82 (5), p.843-859

2012

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Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5‑HT6 Serotoninergic Receptors

Journal of medicinal chemistry, 2014-05, Vol.57 (9), p.3884-3890

2014

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Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding

The European journal of neuroscience, 2019-07, Vol.50 (1), p.1831-1842

2019

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Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein

Journal of medicinal chemistry, 2010-07, Vol.53 (14), p.5144-5154

2010

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Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4580-4596

2013

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Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Molecular pharmacology, 2009-06, Vol.75 (6), p.1412-1420

2009

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Novel Pyrazolo[1,5‑a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [18F]-Labeling, and in Vivo Neuroinflammation PET Images

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7449-7464

2015

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Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4752-4772

2011

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Sialorphin Potentiates Effects of [Met 5 ]Enkephalin without Toxicity by Action other than Peptidase Inhibition

The Journal of pharmacology and experimental therapeutics, 2020-10, Vol.375 (1), p.104

2020

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Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5995-6008

2004

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CNS 7056: a novel ultra-short-acting Benzodiazepine

Anesthesiology (Philadelphia), 2007-07, Vol.107 (1), p.60-66

2007

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Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus

The Journal of neuroscience, 2015-07, Vol.35 (26), p.9622-9631

2015

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Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer’s Disease Brain

Assessment of angiotensin II receptor blockade in humans using a standardized angiotensin II receptor-binding assay

High-affinity [ 3H] kainic acid binding to brain membranes : a re-evaluation of ligand potency and selectivity

Evaluating kratom alkaloids using PHASE

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Synthesis and Biological Investigation of Coumarin Piperazine (Piperidine) Derivatives as Potential Multireceptor Atypical Antipsychotics

The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium

Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor

Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5‑HT6 Serotoninergic Receptors

Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding

Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein

Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones

Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice

Novel Pyrazolo[1,5‑a]pyrimidines as Translocator Protein 18 kDa (TSPO) Ligands: Synthesis, in Vitro Biological Evaluation, [18F]-Labeling, and in Vivo Neuroinflammation PET Images

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

Sialorphin Potentiates Effects of [Met 5 ]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist

CNS 7056: a novel ultra-short-acting Benzodiazepine

Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus

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