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The biology of IQGAP proteins: beyond the cytoskeleton

EMBO reports, 2015-04, Vol.16 (4), p.427-446

2015

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11381-11386

2011

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SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6686), p.eadk1291

2024

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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

eLife, 2020-06, Vol.9

2020

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Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Cell death and differentiation, 2017-01, Vol.24 (1), p.15-25

2017

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Journal of cell biology, 2024-09, Vol.223 (9)

2024

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Nature communications, 2019-09, Vol.10 (1), p.3975-13, Article 3975

2019

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The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

The Journal of cell biology, 2023-06, Vol.222 (6), p.1

2023

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IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling

Scientific reports, 2019-05, Vol.9 (1), p.7539-12, Article 7539

2019

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DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer

Cancer letters, 2022-04, Vol.532, p.215588-215588, Article 215588

2022

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IQGAP1 Regulates Actin Polymerization and Contributes to Bleomycin-Induced Lung Fibrosis

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5244

2024

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Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

Nature cell biology, 2016-12, Vol.18 (12), p.1324-1335

2016

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IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4545

2024

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Single-molecule imaging of a three-component ordered actin disassembly mechanism

Nature communications, 2015-05, Vol.6 (1), p.7202-7202, Article 7202

2015

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Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

Scientific reports, 2017-07, Vol.7 (1), p.5272-12, Article 5272

2017

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interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA

The Journal of cell biology, 2008-06, Vol.181 (6), p.985-998

2008

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Identification of RASAL1 as a Major Tumor Suppressor Gene in Thyroid Cancer

JNCI : Journal of the National Cancer Institute, 2013-11, Vol.105 (21), p.1617-1627

2013

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Elucidating microscopic events driven by GTP hydrolysis reaction in the Ras-GAP system with semi-reactive molecular dynamics simulations: the alternative role of a phosphate binding loop for mechanical energy storage

Physical chemistry chemical physics : PCCP, 2021-12, Vol.23 (46), p.26151-26164

2021

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SUMOylation of IQGAP1 promotes the development of colorectal cancer

Cancer letters, 2017-12, Vol.411, p.90-99

2017

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Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras

Scientific reports, 2019-07, Vol.9 (1), p.11057-13, Article 11057

2019

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The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes

The Journal of cell biology, 2024-06, Vol.223 (6)

2024

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Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis

Genes to cells : devoted to molecular & cellular mechanisms, 2014-11, Vol.19 (11), p.803-820

2014

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Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity

Scientific reports, 2020-04, Vol.10 (1), p.5753-5753, Article 5753

2020

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Simvastatin preparations promote PDGF‐BB secretion to repair LPS‐induced endothelial injury through the PDGFRβ/PI3K/Akt/IQGAP1 signalling pathway

Journal of cellular and molecular medicine, 2019-12, Vol.23 (12), p.8314-8327

2019

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DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (47), p.19878-19883

2009

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The biology of IQGAP proteins: beyond the cytoskeleton

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling

DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer

IQGAP1 Regulates Actin Polymerization and Contributes to Bleomycin-Induced Lung Fibrosis

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases

Single-molecule imaging of a three-component ordered actin disassembly mechanism

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling

interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA

Identification of RASAL1 as a Major Tumor Suppressor Gene in Thyroid Cancer

Elucidating microscopic events driven by GTP hydrolysis reaction in the Ras-GAP system with semi-reactive molecular dynamics simulations: the alternative role of a phosphate binding loop for mechanical energy storage

SUMOylation of IQGAP1 promotes the development of colorectal cancer

Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras

The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes

Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity

Simvastatin preparations promote PDGF‐BB secretion to repair LPS‐induced endothelial injury through the PDGFRβ/PI3K/Akt/IQGAP1 signalling pathway

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

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