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Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development

Journal of molecular medicine (Berlin, Germany), 2010-02, Vol.88 (2), p.135-142

Malley, Richard

2010

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Serotype replacement in disease after pneumococcal vaccination

The Lancet (British edition), 2011-12, Vol.378 (9807), p.1962-1973

2011

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Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines

Expert review of vaccines, 2023-12, Vol.22 (1), p.118-138

2023

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Rationale and prospects for novel pneumococcal vaccines

Human vaccines & immunotherapeutics, 2016-02, Vol.12 (2), p.383-392

2016

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Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (10), p.3623-3627

2012

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Multiple antigen presenting system (MAPS): state of the art and potential applications

Expert review of vaccines, 2024, Vol.23 (1), p.196-204

2024

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CD4+T Cells Mediate Antibody-Independent Acquired Immunity to Pneumococcal Colonization

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (13), p.4848-4853

2005

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Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine

PloS one, 2012, Vol.7 (8), p.e43445-e43445

2012

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Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model

Infection and Immunity, 2009-04, Vol.77 (4), p.1613-1622

2009

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Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide

Infection and Immunity, 2006-04, Vol.74 (4), p.2187-2195

2006

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Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae

PLoS pathogens, 2012-11, Vol.8 (11), p.e1002989-e1002989

2012

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Protection against Pneumococcal Colonization and Fatal Pneumonia by a Trivalent Conjugate of a Fusion Protein with the Cell Wall Polysaccharide

Infection and Immunity, 2009-05, Vol.77 (5), p.2076-2083

2009

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Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model

Infection and Immunity, 2005-10, Vol.73 (10), p.7043-7046

2005

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Antibody-Independent, CD4⁺ T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Infection and Immunity, 2007-11, Vol.75 (11), p.5460-5464

2007

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Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?

PLoS medicine, 2005-01, Vol.2 (1), p.e15-e15

2005

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Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

Clinical and Vaccine Immunology, 2010-06, Vol.17 (6), p.1005-1012

2010

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Association of the Pneumococcal Pilus with Certain Capsular Serotypes but Not with Increased Virulence

Journal of Clinical Microbiology, 2007-06, Vol.45 (6), p.1684-1689

2007

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Recombinant Bactericidal/Permeability-Increasing Protein rBPI₂₁ Protects against Pneumococcal Disease

Infection and Immunity, 2007-01, Vol.75 (1), p.342-349

2007

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Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies

Clinical and vaccine immunology, 2016-02, Vol.23 (2), p.162-167

2016

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Induction of T Cell Responses by Vaccination of a Streptococcus pneumoniae Whole-Cell Vaccine

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2410, p.345

2022

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Evaluation of the Role of stat3 in Antibody and T H 17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome

Infection and immunity, 2018-05, Vol.86 (5)

2018

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Multiserotype Protection of Mice against Pneumococcal Colonization of the Nasopharynx and Middle Ear by Killed Nonencapsulated Cells Given Intranasally with a Nontoxic Adjuvant

Infection and Immunity, 2004-07, Vol.72 (7), p.4290-4292

2004

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Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Infection and immunity, 2018-11, Vol.86 (11)

2018

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Safety, tolerability and immunogenicity of a novel 24-valent pneumococcal vaccine in toddlers: A phase 1 randomized controlled trial

Vaccine, 2024-04, Vol.42 (10), p.2560-2571

2024

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A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults

The Pediatric infectious disease journal, 2020-04, Vol.39 (4), p.345

2020

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Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development

Serotype replacement in disease after pneumococcal vaccination

Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines

Rationale and prospects for novel pneumococcal vaccines

Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity

Multiple antigen presenting system (MAPS): state of the art and potential applications

CD4+T Cells Mediate Antibody-Independent Acquired Immunity to Pneumococcal Colonization

Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine

Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model

Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide

Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae

Protection against Pneumococcal Colonization and Fatal Pneumonia by a Trivalent Conjugate of a Fusion Protein with the Cell Wall Polysaccharide

Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model

Antibody-Independent, CD4⁺ T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

Association of the Pneumococcal Pilus with Certain Capsular Serotypes but Not with Increased Virulence

Recombinant Bactericidal/Permeability-Increasing Protein rBPI₂₁ Protects against Pneumococcal Disease

Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies

Induction of T Cell Responses by Vaccination of a Streptococcus pneumoniae Whole-Cell Vaccine

Evaluation of the Role of stat3 in Antibody and T H 17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome

Multiserotype Protection of Mice against Pneumococcal Colonization of the Nasopharynx and Middle Ear by Killed Nonencapsulated Cells Given Intranasally with a Nontoxic Adjuvant

Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

Safety, tolerability and immunogenicity of a novel 24-valent pneumococcal vaccine in toddlers: A phase 1 randomized controlled trial

A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults

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