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Nutritional Signaling via Free Fatty Acid Receptors

International Journal of Molecular Sciences, 2016-03, Vol.17 (4), p.450-450

2016

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In silico and in vitro screening for potential anticancer candidates targeting GPR120

Bioorganic & medicinal chemistry letters, 2021-01, Vol.31, p.127672, Article 127672

2021

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Immunomodulatory Activity of Docosahexenoic Acid on RAW264.7 Cells Activation through GPR120-Mediated Signaling Pathway

Journal of agricultural and food chemistry, 2018-01, Vol.66 (4), p.926-934

2018

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Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device

Sensors (Basel, Switzerland), 2019-04, Vol.19 (7), p.1663

2019

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Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Bioorganic & medicinal chemistry letters, 2014-07, Vol.24 (14), p.3100-3103

2014

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Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15), p.2599-2604

2018

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Effects of Edible Oils with Different n‑6/n‑3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway

Journal of agricultural and food chemistry, 2020-11, Vol.68 (45), p.12641-12650

2020

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Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

Bioorganic chemistry, 2021-03, Vol.108, p.104657, Article 104657

2021

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DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells

International journal of molecular sciences, 2023-09, Vol.24 (17), p.13325

2023

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GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

International journal of molecular sciences, 2021-10, Vol.22 (19), p.10544

2021

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Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7072

2023

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Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Molecules (Basel, Switzerland), 2021-11, Vol.26 (22), p.6907

2021

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Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists

Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (24), p.127650-127650, Article 127650

2020

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Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120

Frontiers in chemistry, 2022-01, Vol.10, p.816014-816014

2022

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Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption

International journal of molecular sciences, 2023-12, Vol.24 (23), p.17000

2023

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Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

International journal of molecular sciences, 2019-05, Vol.20 (11), p.2625

2019

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Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs

International journal of molecular sciences, 2021-05, Vol.22 (11), p.5748

2021

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Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy

Acta pharmacologica Sinica, 2021-02, Vol.42 (2), p.252-263

2021

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Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus

Molecules (Basel, Switzerland), 2022-12, Vol.27 (24), p.9018

2022

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Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

International journal of molecular sciences, 2024-06, Vol.25 (11), p.5866

2024

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N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5476

2024

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Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Chemistry & biodiversity, 2023-01, Vol.20 (1), p.e202200814-n/a

2023

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Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Bioorganic & medicinal chemistry letters, 2018-03, Vol.28 (5), p.841-846

2018

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Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression

Acta pharmacologica Sinica, 2017-02, Vol.38 (2), p.192-200

2017

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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1278-1283

2017

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Nutritional Signaling via Free Fatty Acid Receptors

In silico and in vitro screening for potential anticancer candidates targeting GPR120

Immunomodulatory Activity of Docosahexenoic Acid on RAW264.7 Cells Activation through GPR120-Mediated Signaling Pathway

Use of Surface-Enhanced Raman Scattering (SERS) Probes to Detect Fatty Acid Receptor Activity in a Microfluidic Device

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design

Effects of Edible Oils with Different n‑6/n‑3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway

Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway

DHA-Provoked Reduction in Adipogenesis and Glucose Uptake Could Be Mediated by Gps2 Upregulation in Immature 3T3-L1 Cells

GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists

Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120

Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption

Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

Isoprenoid Derivatives of Lysophosphatidylcholines Enhance Insulin and GLP-1 Secretion through Lipid-Binding GPCRs

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy

Discovery of Novel and Selective G-Protein Coupled Receptor 120 (GPR120) Agonists for the Treatment of Type 2 Diabetes Mellitus

Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1/Th17 and Treg Cells

N-3 Polyunsaturated Fatty Acids Protect against Alcoholic Liver Steatosis by Activating FFA4 in Kupffer Cells

Diphenyl Ether Derivatives as Novel GPR120 Agonists for the Treatment of Type 2 Diabetes Mellitus

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

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