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Synthesis of non-competitive inhibitors of Sphingomyelinases with significant activity

Bioorganic & medicinal chemistry letters, 2003-01, Vol.13 (2), p.229-236

2003

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Synthesis of acyclic nucleotide analogues possessing a difluoromethylene phosphonyl group at the side chain

Tetrahedron, 2003-12, Vol.59 (51), p.10223-10230

2003

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N-Glycosylation of 2,3-dideoxyfuranose derivatives having a (diethoxyphosphorothioyl)difluoromethyl group at the 3α-position

Tetrahedron, 2003-11, Vol.59 (46), p.9059-9073

2003

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Improved Synthesis of 1,3-Propanediol Derivatives Having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position: Application to Chemoenzymatic Synthesis of Novel Acyclic Nucleotide Analogues of Adenosine Bisphosphates

Synthesis (Stuttgart), 2005-02, Vol.2005 (2), p.187-192

2005

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Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases

Bioorganic & medicinal chemistry, 2000-11, Vol.8 (11), p.2571-2579

2000

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Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. A new class of inhibitors for purine nucleoside phosphorylases

Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (19), p.2833-2836

1999

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Enantioselective synthesis of threo-α,β-dihydroxyphosphonates by asymmetric dihydroxylation of 1( E)-alkenylphosphonates with AD- mix reagents

Tetrahedron, 1998-01, Vol.54 (5), p.767-780

1998

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Simple and Efficient Method for Preparation of Conformationally Constrained Aminomethylene gem-Diphosphonate Derivatives via Beckmann Rearrangement

Journal of organic chemistry, 1994-12, Vol.59 (24), p.7562-7564

1994

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A Practical Synthesis of 8-Hydroxyacyclovir and 9-(Carboxymethoxymethyl)guanine, Metabolites of Acyclovir

Heterocycles, 2005-08, Vol.65 (8), p.1967

2005

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The difluoromethylenephosphonothioic acid group as a phosphate surrogate for obtaining PTP-1B inhibitors. Transformation of difluoromethylenephosphonic acids into difluoromethylenephosphonothioic acids

ARKIVOC, 2003-10, Vol.2003 (8), p.256-266

2003

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Stereoselective Synthesis of Methylenephosphonate Analogues of 2-Deoxyribose 3-Phosphates through Cyclization of Alkyl Radicals to Vinylphosphonates

Synlett, 1995-12, Vol.1995 (12), p.1280-1282

1995

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Enantioselective synthesis of threo- α, β-dihydroxyphosphonates by asymmetric dihydroxylation of vinylphosphonates. An application to the stereocontrolled synthesis of (4 S,5 S)-4-diethylphosphono-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane

Tetrahedron: asymmetry, 1995-02, Vol.6 (2), p.365-368

1995

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Highly Diastereoselective Synthesis of (6-Methylenepyrrolo [1,2-C] oxazol-7-yl)methylphosphonate by an Application of Radical Reaction

Synthetic communications, 1999-10, Vol.29 (20), p.3573-3580

1999

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New entry to diastereoselective synthesis of β,γ-disubstituted γ-lactones. Application to self-immolative enantioselective synthesis of 5-alkylbutenolides

Heterocycles, 1991-12, Vol.32 (12), p.2315-2318

1991

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An efficient diastereoselective synthesis of 6-hydroxy-4a-phenyl-cis-decahydroisoquinolines through N-acyliminium ion induced polyene cyclization

Journal of organic chemistry, 1985-09, Vol.50 (19), p.3449-3453

1985

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Synthesis of oxazolo[4,3-a]isoquinoline and related compounds through intramolecular arylation of α-oxaacyl iminium ions

Journal of organic chemistry, 1983, Vol.48 (21), p.3835-3837

1983

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Diastereoconversion of threo 2-amino alcohols to erythro isomers through a new cyclocarbamation

Heterocycles, 1988, Vol.27 (5), p.1241-1248

1988

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A NEW AND FACILE STEREOSELECTIVE SYNTHESIS OF CIS-4a-ARYL-1,2,3,4,4a,5,6,8a-OCTAHYDROISOQUINOLINE DERIVATIVES

Chemistry letters, 1982-12, Vol.11 (12), p.1915-1918

1982

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ALUMINUM-MEDIATED ONE-POT CONVERSION OF α-AMINO ACID ESTERS TO THREO 2-AMINO ALCOHOLS WITH HIGH DIASTEREOSELECTIVITY

Chemical and Pharmaceutical Bulletin, 1989/10/25, Vol.37(10), pp.2867-2869

1989

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A Synthesis of Simple 4, 4-Disubstituted Tetrahydroisoquinolines by Cyclization of α, α-Disubstituted Phenylacetamides

Chemical and Pharmaceutical Bulletin, 1985/01/25, Vol.33(1), pp.340-346

1985

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A highly diastereoselective synthesis of cis-4a-aryloctahydrocyclopenta(c)pyridine derivatives through tandem radical cyclization of .ALPHA.-amino radical-polyene species

Chemical & pharmaceutical bulletin, 1988, Vol.36 (8), p.2934-2939

1988

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A Formation of Pyrrolo[2,1-a]isoquinoline Derivatives by the Reaction of Isoquinoline N-Oxides with Ethyl Propiolate

Heterocycles, 1982, Vol.19 (11), p.2143

1982

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Synthesis of thieno [3,4-c] pyridine and thieno [3,4-c] azepine derivatives by N-acyliminium ion-induced cyclization

Heterocycles, 1983, Vol.20 (12), p.2411-2416

1983

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A Stereoselective Synthesis of 1,5-Disubstituted Thieno[3',2':3,4]piperidino[1,2-c]oxazolidin-3-ones through N-Oxaacyliminium Ion Cyclization

Heterocycles, 1984, Vol.22 (6), p.1411

1984

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The Stevens Rearrangement of Quarternary Isoquinolinium Salts

Chemical and Pharmaceutical Bulletin, 1977/10/25, Vol.25(10), pp.2510-2515

1977

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Synthesis of non-competitive inhibitors of Sphingomyelinases with significant activity

Synthesis of acyclic nucleotide analogues possessing a difluoromethylene phosphonyl group at the side chain

N-Glycosylation of 2,3-dideoxyfuranose derivatives having a (diethoxyphosphorothioyl)difluoromethyl group at the 3α-position

Improved Synthesis of 1,3-Propanediol Derivatives Having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position: Application to Chemoenzymatic Synthesis of Novel Acyclic Nucleotide Analogues of Adenosine Bisphosphates

Synthesis and evaluation of multisubstrate analogue inhibitors of purine nucleoside phosphorylases

Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. A new class of inhibitors for purine nucleoside phosphorylases

Enantioselective synthesis of threo-α,β-dihydroxyphosphonates by asymmetric dihydroxylation of 1( E)-alkenylphosphonates with AD- mix reagents

Simple and Efficient Method for Preparation of Conformationally Constrained Aminomethylene gem-Diphosphonate Derivatives via Beckmann Rearrangement

A Practical Synthesis of 8-Hydroxyacyclovir and 9-(Carboxymethoxymethyl)guanine, Metabolites of Acyclovir

The difluoromethylenephosphonothioic acid group as a phosphate surrogate for obtaining PTP-1B inhibitors. Transformation of difluoromethylenephosphonic acids into difluoromethylenephosphonothioic acids

Stereoselective Synthesis of Methylenephosphonate Analogues of 2-Deoxyribose 3-Phosphates through Cyclization of Alkyl Radicals to Vinylphosphonates

Enantioselective synthesis of threo- α, β-dihydroxyphosphonates by asymmetric dihydroxylation of vinylphosphonates. An application to the stereocontrolled synthesis of (4 S,5 S)-4-diethylphosphono-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane

Highly Diastereoselective Synthesis of (6-Methylenepyrrolo [1,2-C] oxazol-7-yl)methylphosphonate by an Application of Radical Reaction

New entry to diastereoselective synthesis of β,γ-disubstituted γ-lactones. Application to self-immolative enantioselective synthesis of 5-alkylbutenolides

An efficient diastereoselective synthesis of 6-hydroxy-4a-phenyl-cis-decahydroisoquinolines through N-acyliminium ion induced polyene cyclization

Synthesis of oxazolo[4,3-a]isoquinoline and related compounds through intramolecular arylation of α-oxaacyl iminium ions

Diastereoconversion of threo 2-amino alcohols to erythro isomers through a new cyclocarbamation

A NEW AND FACILE STEREOSELECTIVE SYNTHESIS OF CIS-4a-ARYL-1,2,3,4,4a,5,6,8a-OCTAHYDROISOQUINOLINE DERIVATIVES

ALUMINUM-MEDIATED ONE-POT CONVERSION OF α-AMINO ACID ESTERS TO THREO 2-AMINO ALCOHOLS WITH HIGH DIASTEREOSELECTIVITY

A Synthesis of Simple 4, 4-Disubstituted Tetrahydroisoquinolines by Cyclization of α, α-Disubstituted Phenylacetamides

A highly diastereoselective synthesis of cis-4a-aryloctahydrocyclopenta(c)pyridine derivatives through tandem radical cyclization of .ALPHA.-amino radical-polyene species

A Formation of Pyrrolo[2,1-a]isoquinoline Derivatives by the Reaction of Isoquinoline N-Oxides with Ethyl Propiolate

Synthesis of thieno [3,4-c] pyridine and thieno [3,4-c] azepine derivatives by N-acyliminium ion-induced cyclization

A Stereoselective Synthesis of 1,5-Disubstituted Thieno[3',2':3,4]piperidino[1,2-c]oxazolidin-3-ones through N-Oxaacyliminium Ion Cyclization

The Stevens Rearrangement of Quarternary Isoquinolinium Salts

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